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Systemic mastocytosis identified in two women developing fragility fractures during lactation
Zhu, J. J. Mahendran, D. Lee, M.H. Seah, J. Fourlanos, S. Varadarajan, S. Ghasem-Zadeh, Ali MacIsaac, Richard Seeman, Ego
Zhu, J. J.
Mahendran, D.
Lee, M.H.
Seah, J.
Fourlanos, S.
Varadarajan, S.
Ghasem-Zadeh, Ali
MacIsaac, Richard
Seeman, Ego
Abstract
Two women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29 years old with a BMD T-score of − 3.2 SD at the spine and− 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of − 4.5 SD at the spine and − 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investigation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocytosis. Lactation causes bone loss, but the occurrence of fractures in the setting of severe deficits in BMD and microstructural deterioration signals the need to consider additional causes of bone loss.
Keywords
Bone loss, Fractures, Lactation, Mastocytosis, Osteoporosis
Date
2018
Type
Journal article
Journal
Osteoporosis International
Book
Volume
29
Issue
7
Page Range
1671-1674
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled