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Value of biomarkers in osteoarthritis: Current status and perspectives
Lotz, M. Martel-Pelletier, Johanne Christiansen, Claus Brandi, Maria-Luisa Bruyère, O. Chapurlat, Roland D. Collette, J. Cooper, Cyrus Giacovelli, G. Kanis, John A.
Lotz, M.
Martel-Pelletier, Johanne
Christiansen, Claus
Brandi, Maria-Luisa
Bruyère, O.
Chapurlat, Roland D.
Collette, J.
Cooper, Cyrus
Giacovelli, G.
Kanis, John A.
Author
Lotz, M.
Martel-Pelletier, Johanne
Christiansen, Claus
Brandi, Maria-Luisa
Bruyère, O.
Chapurlat, Roland D.
Collette, J.
Cooper, Cyrus
Giacovelli, G.
Kanis, John A.
Karsdal, M. A.
Kraus, V.
Lems, Willem F.
Meulenbelt, I.
Pelletier, Jean-Pierre
Raynauld, J.-P.
Reiter-Niesert, S.
Rizzoli, R.
Sandell, L. J.
Van Spil, W. E.
Reginster, Jean-Yves
Martel-Pelletier, Johanne
Christiansen, Claus
Brandi, Maria-Luisa
Bruyère, O.
Chapurlat, Roland D.
Collette, J.
Cooper, Cyrus
Giacovelli, G.
Kanis, John A.
Karsdal, M. A.
Kraus, V.
Lems, Willem F.
Meulenbelt, I.
Pelletier, Jean-Pierre
Raynauld, J.-P.
Reiter-Niesert, S.
Rizzoli, R.
Sandell, L. J.
Van Spil, W. E.
Reginster, Jean-Yves
Abstract
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls ( diagnostic ) or between patients with different disease severities ( burden of disease ), predict prognosis in individuals with or without osteoarthritis ( prognostic ) or perform so consistently that it could function as a surrogate outcome in clinical trials ( efficacy of intervention ). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the ‘omics’ ( genomics, metabolomics, proteomics and lipidomics ); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis.
Keywords
Date
2013
Type
Journal article
Journal
Annals of the Rheumatic Diseases
Book
Volume
72
Issue
11
Page Range
1756-1763
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
File Access
Open
Notes
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/