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A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression
Sankar, Anjali Melin, Alice Lorenzetti, Valentina Horton, Paul Costafreda, Sergi G. Fu, Cynthia H. Y.
Sankar, Anjali
Melin, Alice
Lorenzetti, Valentina
Horton, Paul
Costafreda, Sergi G.
Fu, Cynthia H. Y.
Abstract
Longitudinal neuroimaging studies in major depression have revealed cortico-limbic abnormalities which are modulated by treatment. We performed a systematic review and meta-analysis of psychotherapy treatment studies measuring neural function and metabolism using fMRI, PET, SPECT and MRS. Seventeen studies were included in the systematic review, total of 200 major depression participants (mean age 37.6 years), all medication free, and 116 healthy controls (mean age 36.4 years). Neuroimaging assessments were performed prior to initiation of treatment and following course of treatment. Treatment durations were: 16–30 weeks for CBT, 11 weeks for behavioral activation therapy, and up to 15 months for psychodynamic psychotherapy. The meta-analysis consisted of studies in which both groups had same serial scans and comparable tasks; total of 5 studies with visual presentation tasks of emotional stimuli: 55 patients (mean age: 38.7 years) and 55 healthy controls (mean age: 36.3 years). The meta-analysis revealed a significant group by time effect in left rostral anterior cingulate, in which patients showed increased activity following psychotherapy while healthy controls showed a decrease at follow up. Longitudinal treatment effects revealed reduced left precentral cortical activity in major depression. Findings could be indicative of improvements in emotion responsivity that may be achieved following psychotherapy.
Keywords
meta-analysis, neuroimaging, major depressive disorder, cognitive behavioral therapy, psychodynamic, interpersonal, psychotherapy, psychological intervention
Date
2018
Type
Journal article
Journal
Psychiatry Research: Neuroimaging
Book
Volume
279
Issue
Page Range
31-39
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled