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Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes
Price, Sarah A. Gorelik, Alexandra Fourlanos, Spiros Colman, Peter G. Wentworth, John M.
Price, Sarah A.
Gorelik, Alexandra
Fourlanos, Spiros
Colman, Peter G.
Wentworth, John M.
Abstract
Excessive body weight is increasingly seen in type 1 diabetes but its impact is debated. To address this uncertainty, we aimed to determine the association between excess body weight and the macro- and microvascular complications of type 1 diabetes. We identified 501 adults with type 1 diabetes attending an Australian hospital clinic and extracted their clinical and biochemical data from our patient management database. In both men and women, obesity (BMI > 30 kg/m2) was the predominant risk factor for retinopathy and cardiovascular disease despite similar HbA1c and increased use of cardioprotective drugs compared to non-obese patients. Obesity was associated with albuminuria in women, but not renal impairment or neuropathy in either sex. We conclude that obesity in type 1 diabetes may promote retinopathy and macrovascular disease. Future trials to determine the effect of weight loss on type 1 diabetes in obese people are needed.
Keywords
type 1 diabetes, obesity, body mass index, macrovascular, complications, microvascular
Date
2014
Type
Journal article
Journal
Obesity Research and Clinical Practice
Book
Volume
8
Issue
2
Page Range
e178-e182
Article Number
ACU Department
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled