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A white paper on collagen hydrolyzates and ultrahydrolyzates : Potential supplements to support joint health in osteoarthritis?
Mobasheri, Ali Mahmoudian, Armaghan Kalvaityte, Ursule Uzieliene, Ilona Larder, Christina E. Iskandar, Michèle M. Kubow, Stan Hamdan, Paulo Cesar de Almeida Jr, Cyro Scala Favazzo, Lacey J.
Mobasheri, Ali
Mahmoudian, Armaghan
Kalvaityte, Ursule
Uzieliene, Ilona
Larder, Christina E.
Iskandar, Michèle M.
Kubow, Stan
Hamdan, Paulo Cesar
de Almeida Jr, Cyro Scala
Favazzo, Lacey J.
Abstract
Purpose of Review
Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure.
Recent Findings
This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements.
Summary
The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
Keywords
joint health, osteoarthritis, nutritional supplement, nutraceutical, denatured collagen, collagen hydrolyzate, collagen ultra-hydrolyzate
Date
2021
Type
Journal article
Journal
Book
Volume
23
Issue
11
Page Range
1-15
Article Number
Article 78
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open