Loading...
Systemic and metabolic signature of sarcopenia in community-dwelling older adults
Lu, Yanxia Karagounis, Leonidas G. Ng, Tze Pin Carre, Christophe Narang, Vipin Wong, Glenn Tan, Crystal Tze Ying Nyunt, Ma Shwe Zin Gao, Qi Abel, Brian
Lu, Yanxia
Karagounis, Leonidas G.
Ng, Tze Pin
Carre, Christophe
Narang, Vipin
Wong, Glenn
Tan, Crystal Tze Ying
Nyunt, Ma Shwe Zin
Gao, Qi
Abel, Brian
Abstract
Background
Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized the nutritional and metabolic profile of sarcopenia through an extensive exploration of a wide array of blood biomarkers related to muscle protein metabolism and transcriptomic signatures in community-dwelling elderly adults.
Methods
Among 189 older individuals with a mean age of 73.2 years, sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia criteria based on appendicular lean mass measured by dual-energy X-ray absorptiometry scan, muscle strength, and gait speed. Nutritional status was evaluated using the mini-nutritional assessment (MNA). In addition, we assessed specific blood biomarkers of nutritional status (plasma essential amino acids [EAAs], vitamins), nicotine-derived metabolites, and an extensive microarray analysis from peripheral blood mononuclear cells.
Results
Malnutrition defined by low MNA score was independently associated with sarcopenia (p < .001). Sarcopenic elderly showed lower body mass index and leptin and higher adiponectin and high-density lipoproteins. Levels of EAAs including lysine, methionine, phenylalanine, threonine, as well as branched-chain AAs and choline, were inversely associated with sarcopenia. Furthermore, nicotine metabolites (cotinine and trans-3′-hydroxycotine) and vitamin B6 status were linked to one or more clinical and functional measures of sarcopenia. Differentially expressed genes and ingenuity pathway analysis supported the association of nutrition with sarcopenia.
Conclusions
Herein, the characterization of a nutritional and metabolic signature of sarcopenia provides a firm basis and potential identification of specific targets and directions for the nutritional approach to the prevention and treatment of sarcopenia in aging populations.
Keywords
sarcopenia, nutrition, metabolites, ingenuity pathway analysis, modifiable risk factors
Date
2020
Type
Journal article
Journal
Journals of Gerontology: Series A Biological Sciences and Medical Sciences
Book
Volume
75
Issue
2
Page Range
309-317
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC 4.0
File Access
Open