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The LifeCycle Project-EU Child Cohort Network : A federated analysis infrastructure and harmonized data of more than 250,000 children and parents
Jaddoe, Vincent W. V. Felix, Janine F. Andersen, Anne-Marie Nybo Charles, Marie-Aline Chatzi, Leda Corpeleijn, Eva Donner, Nina Elhakeem, Ahmed Eriksson, Johan G. Foong, Rachel
Jaddoe, Vincent W. V.
Felix, Janine F.
Andersen, Anne-Marie Nybo
Charles, Marie-Aline
Chatzi, Leda
Corpeleijn, Eva
Donner, Nina
Elhakeem, Ahmed
Eriksson, Johan G.
Foong, Rachel
Author
Jaddoe, Vincent W. V.
Felix, Janine F.
Andersen, Anne-Marie Nybo
Charles, Marie-Aline
Chatzi, Leda
Corpeleijn, Eva
Donner, Nina
Elhakeem, Ahmed
Eriksson, Johan G.
Foong, Rachel
Grote, Veit
Haakma, Sido
Haakma, Sido
Harris, Jennifer R.
Heude, Barbara
Huang, Rae-Chi
Inskip, Hazel
Järvelin, Marjo-Riitta
Koletzko, Berthold
Lawlor, Deborah A.
Lindeboom, Maarten
McEachan, Rosemary R. C.
Mikkola, Tuija M.
Nader, Johanna L. T.
de Moira, Angela Pinot
Pizzi, Costanza
Richiardi, Lorenzo
Sebert, Sylvain
Schwalber, Ameli
Sunyer, Jordi
Swertz, Morris A.
Vafeiadi, Marina
Vrijheid, Martine
Wright, John
Duijts, Liesbeth
Jaddoe, Vincent W. V.
Felix, Janine F.
El Marroun, Hanan
Gaillard, Romy
Santos, Susana
Geurtsen, Madelon L.
Kooijman, Marjolein N.
Mensink-Bout, Sara M.
Vehmeijer, Florianne O. L.
Voerman, Ellis
Vrijheid, Martine
Sunyer, Jordi
Nieuwenhuijsen, Mark
Basagaña, Xavier
Bustamante, Mariona
Casas, Maribel
de Castro, Montserrat
Cirugeda, Lourdes E.
Fernández-Barrés, Sílvia
Fossati, Serena
Garcia, Raquel
Júlvez, Jordi
Lertxundi, Aitana C.
Lertxundi, Nerea
Llop, Sabrina
López-Vicente, Mònica
Lopez-Espinosa, Maria-Jose B.
Maitre, Lea
Murcia, Mario
Lea, Jose
Urquiza, H.
Warembourg, Charline
Richiardi, Lorenzo
Pizzi, Costanza
Zugna, Daniela
Popovic, Maja
Isaevska, Elena
Maule, Milena
Moccia, Chiara
Moirano, Giovenale
Rasella, Davide
Hanson, Mark A.
Inskip, Hazel M.
Jacob, Chandni Maria
Salika, Theodosia
Lawlor, Deborah A.
Elhakeem, Ahmed
Cadman, Tim
Andersen, Anne-Marie Nybo
de Moira, Angela Pinot
Strandberg-Larsen, Katrine M.
Pedersen, Marie
Vinther, Johan L.
Wright, John
McEachan, Rosemary R. C.
Wilson, Paul
Mason, Dan
Yang, Tiffany C.
Swertz, Morris A.
Corpeleijn, Eva
Haakma, Sido
Cardol, Marloes
van Enckevoort, Esther
Hyde, Eleanor
Scholtens, Salome
Snieder, Harold
Thio, Chris H. L.
Vafeiadi, Marina
Chatzi, Lida
Margetaki, Katerina C. A.
Roumeliotaki, Theano
Harris, Jennifer R.
Nader, Johanna L.
Knudsen, Gun Peggy
Magnus, Per
Charles, Marie-Aline
Heude, Barbara
Panico, Lidia
Ichou, Mathieu
de Lauzon-Guillain, Blandine
Dargent-Molina, Patricia
Cornet, Maxime
Florian, Sandra M.
Harrar, Faryal
Lepeule, Johanna
Lioret, Sandrine
Melchior, Maria
Plancoulaine, Sabine
Järvelin, Marjo-Riitta
Sebert, Sylvain
Männikkö, Minna
Parmar, Priyanka
Rautio, Nina
Ronkainen, Justiina
Tolvanen, Mimmi
Eriksson, Johan G.
Mikkola, Tuija M
Koletzko, Berthold
Grote, Veit
Aumüller, Nicole
Closa-Monasterolo, Ricardo
Escribano, Joaquin
Ferré, Natalia
Gruszfeld, Dariusz
Gürlich, Kathrin
Langhendries, Jean-Paul
Luque, Veronica
Riva, Enrica
Schwarzfischer, Phillipp
Totzauer, Martina
Verduci, Elvira
Xhonneux, Annick
Zaragoza-Jordana, Marta
Lindeboom, Maarten
Schwalber, Amelie
Donner, Nina
Huang, Rae-Chi
Foong, Rachel E.
Hall, Graham L.
Lin, Ashleigh
Carson, Jennie
Melton, Phillip
Rauschert, Sebastian
Felix, Janine F.
Andersen, Anne-Marie Nybo
Charles, Marie-Aline
Chatzi, Leda
Corpeleijn, Eva
Donner, Nina
Elhakeem, Ahmed
Eriksson, Johan G.
Foong, Rachel
Grote, Veit
Haakma, Sido
Haakma, Sido
Harris, Jennifer R.
Heude, Barbara
Huang, Rae-Chi
Inskip, Hazel
Järvelin, Marjo-Riitta
Koletzko, Berthold
Lawlor, Deborah A.
Lindeboom, Maarten
McEachan, Rosemary R. C.
Mikkola, Tuija M.
Nader, Johanna L. T.
de Moira, Angela Pinot
Pizzi, Costanza
Richiardi, Lorenzo
Sebert, Sylvain
Schwalber, Ameli
Sunyer, Jordi
Swertz, Morris A.
Vafeiadi, Marina
Vrijheid, Martine
Wright, John
Duijts, Liesbeth
Jaddoe, Vincent W. V.
Felix, Janine F.
El Marroun, Hanan
Gaillard, Romy
Santos, Susana
Geurtsen, Madelon L.
Kooijman, Marjolein N.
Mensink-Bout, Sara M.
Vehmeijer, Florianne O. L.
Voerman, Ellis
Vrijheid, Martine
Sunyer, Jordi
Nieuwenhuijsen, Mark
Basagaña, Xavier
Bustamante, Mariona
Casas, Maribel
de Castro, Montserrat
Cirugeda, Lourdes E.
Fernández-Barrés, Sílvia
Fossati, Serena
Garcia, Raquel
Júlvez, Jordi
Lertxundi, Aitana C.
Lertxundi, Nerea
Llop, Sabrina
López-Vicente, Mònica
Lopez-Espinosa, Maria-Jose B.
Maitre, Lea
Murcia, Mario
Lea, Jose
Urquiza, H.
Warembourg, Charline
Richiardi, Lorenzo
Pizzi, Costanza
Zugna, Daniela
Popovic, Maja
Isaevska, Elena
Maule, Milena
Moccia, Chiara
Moirano, Giovenale
Rasella, Davide
Hanson, Mark A.
Inskip, Hazel M.
Jacob, Chandni Maria
Salika, Theodosia
Lawlor, Deborah A.
Elhakeem, Ahmed
Cadman, Tim
Andersen, Anne-Marie Nybo
de Moira, Angela Pinot
Strandberg-Larsen, Katrine M.
Pedersen, Marie
Vinther, Johan L.
Wright, John
McEachan, Rosemary R. C.
Wilson, Paul
Mason, Dan
Yang, Tiffany C.
Swertz, Morris A.
Corpeleijn, Eva
Haakma, Sido
Cardol, Marloes
van Enckevoort, Esther
Hyde, Eleanor
Scholtens, Salome
Snieder, Harold
Thio, Chris H. L.
Vafeiadi, Marina
Chatzi, Lida
Margetaki, Katerina C. A.
Roumeliotaki, Theano
Harris, Jennifer R.
Nader, Johanna L.
Knudsen, Gun Peggy
Magnus, Per
Charles, Marie-Aline
Heude, Barbara
Panico, Lidia
Ichou, Mathieu
de Lauzon-Guillain, Blandine
Dargent-Molina, Patricia
Cornet, Maxime
Florian, Sandra M.
Harrar, Faryal
Lepeule, Johanna
Lioret, Sandrine
Melchior, Maria
Plancoulaine, Sabine
Järvelin, Marjo-Riitta
Sebert, Sylvain
Männikkö, Minna
Parmar, Priyanka
Rautio, Nina
Ronkainen, Justiina
Tolvanen, Mimmi
Eriksson, Johan G.
Mikkola, Tuija M
Koletzko, Berthold
Grote, Veit
Aumüller, Nicole
Closa-Monasterolo, Ricardo
Escribano, Joaquin
Ferré, Natalia
Gruszfeld, Dariusz
Gürlich, Kathrin
Langhendries, Jean-Paul
Luque, Veronica
Riva, Enrica
Schwarzfischer, Phillipp
Totzauer, Martina
Verduci, Elvira
Xhonneux, Annick
Zaragoza-Jordana, Marta
Lindeboom, Maarten
Schwalber, Amelie
Donner, Nina
Huang, Rae-Chi
Foong, Rachel E.
Hall, Graham L.
Lin, Ashleigh
Carson, Jennie
Melton, Phillip
Rauschert, Sebastian
Abstract
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.
Keywords
consortium, birth cohorts, exposome, life course, non-communicable diseases
Date
2020
Type
Journal article
Journal
European Journal of Epidemiology
Book
Volume
35
Issue
7
Page Range
709-724
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open