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Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study
Larivière, Sara Rodríguez-Cruces, Raúl Royer, Jessica Caligiuri, Maria Eugenia Gambardella, Antonio Concha, Luis Keller, Simon S. Cendes, Fernando Yasuda, Clarissa Bonilha, Leonardo
Larivière, Sara
Rodríguez-Cruces, Raúl
Royer, Jessica
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa
Bonilha, Leonardo
Author
Larivière, Sara
Rodríguez-Cruces, Raúl
Royer, Jessica
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa
Bonilha, Leonardo
Gleichgerrcht, Ezequiel
Focke, Niels K.
Domin, Martin
von Podewills, Felix
Langner, Soenke
Rummel, Christian
Wiest, Roland
Martin, Pascal
Kotikalapudi, Raviteja
O’Brien, Terence J.
Sinclair, Benjamin
Vivash, Lucy
Desmond, Patricia M.
Alhusaini, Saud
Doherty, Colin P.
Doherty, Colin P.
Delanty, Norman
Kälviäinen, Reetta
Jackson, Graeme D.
Kowalczyk, Magdalena
Mascalchi, Mario
Semmelroch, Mira
Thomas, Rhys H.
Soltanian-Zadeh, Hamid
Davoodi-Bojd, Esmaeil
Zhang, Junsong
Lenge, Matteo
Guerrini, Renzo
Bartolini, Emanuele
Hamandi, Khalid
Foley, Sonya
Weber, Bernd
Depondt, Chantal
Absil, Julie
Carr, Sarah J. A.
Carr, Sarah J. A.
Richardson, Mark P.
Devinsky, Orrin
Severino, Mariasavina
Striano, Pasquale
Tortora, Domenico
Hatton, Sean N.
Vos, Sjoerd B.
Vos, Sjoerd B.
Whelan, Christopher D.
Thompson, Paul M.
Sisodiya, Sanjay M.
Bernasconi, Andrea
Labate, Angelo
McDonald, Carrie R.
Bernasconi, Neda
Bernhardt, Boris C.
Rodríguez-Cruces, Raúl
Royer, Jessica
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa
Bonilha, Leonardo
Gleichgerrcht, Ezequiel
Focke, Niels K.
Domin, Martin
von Podewills, Felix
Langner, Soenke
Rummel, Christian
Wiest, Roland
Martin, Pascal
Kotikalapudi, Raviteja
O’Brien, Terence J.
Sinclair, Benjamin
Vivash, Lucy
Desmond, Patricia M.
Alhusaini, Saud
Doherty, Colin P.
Doherty, Colin P.
Delanty, Norman
Kälviäinen, Reetta
Jackson, Graeme D.
Kowalczyk, Magdalena
Mascalchi, Mario
Semmelroch, Mira
Thomas, Rhys H.
Soltanian-Zadeh, Hamid
Davoodi-Bojd, Esmaeil
Zhang, Junsong
Lenge, Matteo
Guerrini, Renzo
Bartolini, Emanuele
Hamandi, Khalid
Foley, Sonya
Weber, Bernd
Depondt, Chantal
Absil, Julie
Carr, Sarah J. A.
Carr, Sarah J. A.
Richardson, Mark P.
Devinsky, Orrin
Severino, Mariasavina
Striano, Pasquale
Tortora, Domenico
Hatton, Sean N.
Vos, Sjoerd B.
Vos, Sjoerd B.
Whelan, Christopher D.
Thompson, Paul M.
Sisodiya, Sanjay M.
Bernasconi, Andrea
Labate, Angelo
McDonald, Carrie R.
Bernasconi, Neda
Bernhardt, Boris C.
Abstract
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.
Keywords
Date
2020
Type
Journal article
Journal
Science Advances
Book
Volume
6
Issue
47
Page Range
1-14
Article Number
Article eabc6457
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC 4.0
File Access
Open