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A meta-analysis of reference markers of bone turnover for prediction of fracture
Johansson, Helena Oden, Anders Kanis, John A. McCloskey, Eugene V. Morris, Howard A. Cooper, Cyrus Vasikaran, Samuel
Johansson, Helena
Oden, Anders
Kanis, John A.
McCloskey, Eugene V.
Morris, Howard A.
Cooper, Cyrus
Vasikaran, Samuel
Abstract
Abstract The aim of this report was to summarize the clinical performance of two reference bone turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic review to examine the performance characteristics of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective cohort studies. We excluded cross-sectional studies. Ten potentially eligible publications were identified and six included in the metaanalysis. There was a significant association between s-PINP and the risk of fracture. The hazard ratio per SD increase in s-PINP (gradient of risk [GR]) was 1.23 (95 % CI 1.09–1.39) for men and women combined unadjusted for bone mineral density. There was also a significant association between s-CTX and risk of fracture, GR = 1.18 (95 % CI 1.05–1.34) unadjusted for bone mineral density. For the outcome of hip fracture, the association between s-CTX and risk of fracture was slightly higher, 1.23 (95 % CI 1.04–1.47). Thus, there is a modest but significant association between BTMs and risk of future fractures.
Keywords
Marker of bone turnover, Fracture, Serum procollagen type I N propeptide, Serum carboxy-terminal cross-linking telopeptide of type I collagen, Meta-analysis
Date
2014
Type
Journal article
Journal
Calcified Tissue International
Book
Volume
94
Issue
5
Page Range
560-567
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled