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Device-measured sitting time and musculoskeletal pain in adults with normal glucose metabolism, prediabetes and type 2 diabetes – The Maastricht Study
Dzakpasu, Francis Q. S. Koster, Annemarie Owen, Neville de Galan, Bastiaan E. Carver, Alison Brakenridge, Christian J. Boonen, Annelies Bosma, Hans Dagnelie, Pieter C. Eussen, Simone J. P. M.
Dzakpasu, Francis Q. S.
Koster, Annemarie
Owen, Neville
de Galan, Bastiaan E.
Carver, Alison
Brakenridge, Christian J.
Boonen, Annelies
Bosma, Hans
Dagnelie, Pieter C.
Eussen, Simone J. P. M.
Abstract
Background
Detrimental associations of sedentary behaviour (time spent sitting) with musculoskeletal pain (MSP) conditions have been observed. However, findings on those with, or at risk of, type 2 diabetes (T2D) have not been reported. We examined the linear and non-linear associations of device-measured daily sitting time with MSP outcomes according to glucose metabolism status (GMS).
Methods
Cross-sectional data from 2827 participants aged 40–75 years in the Maastricht Study (1728 with normal glucose metabolism (NGM); 441 with prediabetes; 658 with T2D), for whom valid data were available on activPAL-derived daily sitting time, MSP [neck, shoulder, low back, and knee pain], and GMS. Associations were examined by logistic regression analyses, adjusted serially for relevant confounders, including moderate-to-vigorous intensity physical activity (MVPA) and body mass index (BMI). Restricted cubic splines were used to further examine non-linear relationships.
Results
The fully adjusted model (including BMI, MVPA, and history of cardiovascular disease) showed daily sitting time to be significantly associated with knee pain in the overall sample (OR = 1.07, 95%CI: 1.01–1.12) and in those with T2D (OR = 1.11, 95%CI: 1.00–1.22); this was not statistically significant in those with prediabetes (OR = 1.04, 95%CI: 0.91–1.18) or NGM (OR = 1.05, 95%CI: 0.98–1.13). There were no statistically significant associations between daily sitting time and neck, shoulder, or low back pain in any of the models. Furthermore, the non-linear relationships were statistically non-significant.
Conclusion
Among middle-aged and older adults with T2D, daily sitting time was significantly associated with higher odds of knee pain, but not with neck, shoulder, or low back pain. No significant association was observed in those without T2D for neck, shoulder, low back, or knee pain. Future studies, preferably those utilising prospective designs, could examine additional attributes of daily sitting (e.g., sitting bouts and domain-specific sitting time) and the potential relationships of knee pain with mobility limitations.
Keywords
lower back pain, knees, pain, type 2 diabetes, sedentary behaviour, shoulders, glucose metabolism, physical activity
Date
2023
Type
Journal article
Journal
PLoS ONE
Book
Volume
18
Issue
5
Page Range
1-17
Article Number
Article e0285276
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open
Notes
© 2023 Dzakpasu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited