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Serum glycine levels are associated with cortical bone properties and fractures risk in men
Eriksson, Anna L. Friedrich, Nele Karlsson, Magnus K. Ljunggren, Osten Lorentzon, Mattias Nethander, Maria Wallaschofski, Henri Mellstrom, Dan Ohlsson, Claes
Eriksson, Anna L.
Friedrich, Nele
Karlsson, Magnus K.
Ljunggren, Osten
Lorentzon, Mattias
Nethander, Maria
Wallaschofski, Henri
Mellstrom, Dan
Ohlsson, Claes
Abstract
Context
In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD).
Objective
To investigate associations for serum and urinary glycine levels with BMD, bone microstructure, and fracture risk in men.
Methods
In the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (men, 69-81 years) serum glycine and BMD were measured at baseline (n = 965) and 5-year follow-up (n = 546). Cortical and trabecular bone parameters of the distal tibia were measured at follow-up using high-resolution peripheral quantitative computed tomography. Urinary (n = 2682) glycine was analyzed at baseline. X-ray-validated fractures (n = 594) were ascertained during a median follow-up of 9.6 years. Associations were evaluated using linear regression (bone parameters) or Cox regression (fractures).
Results
Circulating glycine levels were inversely associated with femoral neck (FN)-BMD. A meta-analysis (n = 7543) combining MrOS Sweden data with data from 3 other cohorts confirmed a robust inverse association between serum glycine levels and FN-BMD (P = 7.7 × 10-9). Serum glycine was inversely associated with the bone strength parameter failure load in the distal tibia (P = 0.002), mainly as a consequence of an inverse association with cortical cross-sectional area and a direct association with cortical porosity. Both serum and urinary glycine levels predicted major osteoporotic fractures (serum: hazard ratio [HR] per SD increase = 1.22, 95% CI, 1.05-1.43; urine: HR = 1.13, 95% CI, 1.02-1.24). These fracture associations were only marginally reduced in models adjusted by FRAX with BMD.
Conclusions
Serum and urinary glycine are indirectly associated with FN-BMD and cortical bone strength, and directly associated with fracture risk in men.
Keywords
glycine, BMD, HR-pQCT, fracture, men
Date
2021
Type
Journal article
Journal
The Journal of Clinical Endocrinology and Metabolism
Book
Volume
106
Issue
12
Page Range
5021-5029
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open