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How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review
Freeman, Abigail M. Petrilli, Katherine Lees, Rachel Hindocha, Chandni Mokrysz, Claire Curran, H. Valerie Saunders, Rob Freeman, Tom P.
Freeman, Abigail M.
Petrilli, Katherine
Lees, Rachel
Hindocha, Chandni
Mokrysz, Claire
Curran, H. Valerie
Saunders, Rob
Freeman, Tom P.
Abstract
The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.
Keywords
Date
2019
Type
Journal article
Journal
Neuroscience and Biobehavioral Reviews
Book
Volume
107
Issue
Page Range
696-712
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled