Loading...
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Conti, David V. Darst, B. F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R Olama, Ali Amin Al Benlloch, Sara Dadaev, Tokhir
Conti, David V.
Darst, B. F.
Moss, Lilit C.
Saunders, Edward J.
Sheng, Xin
Chou, Alisha
Schumacher, Fredrick R
Olama, Ali Amin Al
Benlloch, Sara
Dadaev, Tokhir
Author
Conti, David V.
Darst, B. F.
Moss, Lilit C.
Saunders, Edward J.
Sheng, Xin
Chou, Alisha
Schumacher, Fredrick R
Olama, Ali Amin Al
Benlloch, Sara
Dadaev, Tokhir
Brook, Mark N.
Sahimi, Ali
Hoffmann, Thomas J.
Takahashi, Atushi
Matsuda, Koichi
Momozawa, Yukihide
Fujita, Masashi
Muir, Kenneth
Lophatananon, Artitaya
Wan, Peggy
Le Marchand, L.
Wilkens, L.
Stevens, Victoria L.
Gapstur, Susan M.
Carter, Brian D.
Schleutker, Johanna
Tammela, Teuvo L. J.
Sipeky, Csilla
Auvinen, Anssi
Giles, Graham G.
Southey, Melissa C.
MacInnis, Robert J.
Cybulski, Cezary
Wokolorczyk, Dominika
Lubinski, Jan
Neal, David E.
Donovan, Jenny L.
Hamdy, Freddie C.
Martin, Richard M.
Nordestgaard, Børge G.
Nielsen, Sune F.
Weischer, Maren
Bojesen, Stig E.
Røder, Martin Andreas
Iversen, Peter
Batra, Jyotsna
Chambers, Suzanne
Moya, Leire
Horvath, Lisa
Clements, Judith A.
Tilley, Wayne
Risbridger, Gail P.
Grönberg, Henrik
Aly, Markus
Szulkin, Robert
Eklund, Martin
Nordström, Tobias
Pashayan, Nora
Dunning, Alison M.
Ghoussaini, Maya
Travis, Ruth C.
Key, Timothy J.
Riboli, Elio
Park, Jong Y.
Sellers, Thomas A.
Lin, Hui-Yi
Albanes, Demetrius
Weinstein, Stephanie J.
Mucci, Lorelei A.
Giovannucci, Edward
Lindström, Sara
Kraft, Peter
Hunter, David J.
Penney, Kathryn L.
Turman, Constance
Tangen, Catherine M.
Goodman, Phyllis J.
Thompson, Ian M.
Hamilton, Robert J.
Fleshner, Neil E.
Finelli, Antonio
Parent, Marie-Élise
Stanford, Janet L.
Ostrander, Elaine A.
Geybels, Milan S.
Koutros, Stella
Freeman, Laura E. Beane
Stampfer, Meir
Wolk, Alicja
Hakansson, Niclas
Andriole, Gerald L.
Hoover, Robert N.
Machiela, Mitchell J.
Sorensen, Karina Dalsgaard
Borre, Michael
Blot, William J.
Zheng, Wei
Yeboah, Edward D.
Mensah, James E.
Lu, Yong-Jie
Zhang, Hong-Wei
Feng, Ninghan
Mao, Xueying
Wu, Yudong
Zhao, Shan-Chao
Sun, Zan
Thibodeau, Stephen N.
McDonnell, Shannon K.
Schaid, Daniel J.
West, Catharine M. L.
Burnet, Neil
Barnett, Gill
Maier, Christiane
Schnoeller, Thomas
Luedeke, Manuel
Kibel, Adam S.
Drake, Bettina F.
Cussenot, Olivier
Cancel-Tassin, Géraldine
Menegaux, Florence
Truong, Thérèse
Koudou, Yves Akoli
John, Esther M.
Grindedal, Eli Marie
Maehle, Lovise
Khaw, K.T.
Ingles, Sue Ann
Stern, Mariana C.
Vega, Ana
Gómez-Caamaño, Antonio
Fachal, Laura
Rosenstein, Barry S.
Kerns, Sarah L.
Ostrer, Harry
Teixeira, Manuel R.
Paulo, Paula
Brandão, Andreia
Watya, Stephen
Lubwama, Alexander
Bensen, Jeanette T.
Fontham, Elizabeth T. H.
Mohler, James
Taylor, Jack A.
Kogevinas, Manolis
Llorca, Javier
Casta�o-Vinyals, Gemma
Cannon-Albright, Lisa A.
Teerlink, Craig C.
Huff, Chad D.
Strom, Sara S.
Multigner, Luc
Blanchet, Pascal
Brureau, Laurent
Kaneva, Radka P.
Slavov, Chavdar
Mitev, Vanio
Leach, Robin J.
Weaver, Brandi
Brenner, Hermann
Cuk, Katarina
Holleczek, Bernd
Saum, Kai-Uwe
Klein, Eric A.
Hsing, Ann W.
Kittles, Rick A.
Murphy, Adam B.
Logothetis, Christopher J.
Kim, Jeri
Neuhausen, Susan L.
Steele, Linda
Ding, Yuan Chun
Isaacs, William B.
Nemesure, Barbara
Hennis, Anselm J. M.
Carpten, John
Pandha, Hardev
Michael, Agnieszka
De Ruyck, Kim
De Meerleer, Gert
Ost, Piet
Xu, Jianfeng
Razack, Azad
Lim, Jasmine
Teo, Soo-Hwang
Newcomb, Lisa F.
Lin, Daniel W.
Fowke, J.
Neslund-Dudas, Christine
Rybicki, Benjamin A.
Gamulin, Marija
Lessel, Davor
Kulis, Tomislav
Usmani, Nawaid
Singhal, Sandeep
Parliament, Matthew
Claessens, Frank
Joniau, Steven
Van den Broeck, Thomas
Gago-Dominguez, Manuela
Castelao, Jose Esteban
Martinez, Maria Elena
Larkin, Samantha
Townsend, Paul A.
Aukim-Hastie, Claire
Bush, W.S.
Aldrich, Melinda C.
Crawford, D.
Srivastava, Shiv
Cullen, Jennifer C.
Petrovics, Gyorgy
Casey, Graham
Roobol, Monique J.
Jenster, Guido
van Schaik, Ron H. N.
Hu, Jennifer J.
Sanderson, Maureen
Varma, Rohit
McKean-Cowdin, Roberta
Torres, Mina
Mancuso, Nicholas
Berndt, S.I.
Van Den Eeden, Stephen K.
Easton, Douglas F.
Chanock, Stephen J.
Cook, Michael B.
Wiklund, Fredrik
Nakagawa, Hidewaki
Witte, John S.
Eeles, Rosalind A.
Kote-Jarai, Zsofia
Haiman, C.
Darst, B. F.
Moss, Lilit C.
Saunders, Edward J.
Sheng, Xin
Chou, Alisha
Schumacher, Fredrick R
Olama, Ali Amin Al
Benlloch, Sara
Dadaev, Tokhir
Brook, Mark N.
Sahimi, Ali
Hoffmann, Thomas J.
Takahashi, Atushi
Matsuda, Koichi
Momozawa, Yukihide
Fujita, Masashi
Muir, Kenneth
Lophatananon, Artitaya
Wan, Peggy
Le Marchand, L.
Wilkens, L.
Stevens, Victoria L.
Gapstur, Susan M.
Carter, Brian D.
Schleutker, Johanna
Tammela, Teuvo L. J.
Sipeky, Csilla
Auvinen, Anssi
Giles, Graham G.
Southey, Melissa C.
MacInnis, Robert J.
Cybulski, Cezary
Wokolorczyk, Dominika
Lubinski, Jan
Neal, David E.
Donovan, Jenny L.
Hamdy, Freddie C.
Martin, Richard M.
Nordestgaard, Børge G.
Nielsen, Sune F.
Weischer, Maren
Bojesen, Stig E.
Røder, Martin Andreas
Iversen, Peter
Batra, Jyotsna
Chambers, Suzanne
Moya, Leire
Horvath, Lisa
Clements, Judith A.
Tilley, Wayne
Risbridger, Gail P.
Grönberg, Henrik
Aly, Markus
Szulkin, Robert
Eklund, Martin
Nordström, Tobias
Pashayan, Nora
Dunning, Alison M.
Ghoussaini, Maya
Travis, Ruth C.
Key, Timothy J.
Riboli, Elio
Park, Jong Y.
Sellers, Thomas A.
Lin, Hui-Yi
Albanes, Demetrius
Weinstein, Stephanie J.
Mucci, Lorelei A.
Giovannucci, Edward
Lindström, Sara
Kraft, Peter
Hunter, David J.
Penney, Kathryn L.
Turman, Constance
Tangen, Catherine M.
Goodman, Phyllis J.
Thompson, Ian M.
Hamilton, Robert J.
Fleshner, Neil E.
Finelli, Antonio
Parent, Marie-Élise
Stanford, Janet L.
Ostrander, Elaine A.
Geybels, Milan S.
Koutros, Stella
Freeman, Laura E. Beane
Stampfer, Meir
Wolk, Alicja
Hakansson, Niclas
Andriole, Gerald L.
Hoover, Robert N.
Machiela, Mitchell J.
Sorensen, Karina Dalsgaard
Borre, Michael
Blot, William J.
Zheng, Wei
Yeboah, Edward D.
Mensah, James E.
Lu, Yong-Jie
Zhang, Hong-Wei
Feng, Ninghan
Mao, Xueying
Wu, Yudong
Zhao, Shan-Chao
Sun, Zan
Thibodeau, Stephen N.
McDonnell, Shannon K.
Schaid, Daniel J.
West, Catharine M. L.
Burnet, Neil
Barnett, Gill
Maier, Christiane
Schnoeller, Thomas
Luedeke, Manuel
Kibel, Adam S.
Drake, Bettina F.
Cussenot, Olivier
Cancel-Tassin, Géraldine
Menegaux, Florence
Truong, Thérèse
Koudou, Yves Akoli
John, Esther M.
Grindedal, Eli Marie
Maehle, Lovise
Khaw, K.T.
Ingles, Sue Ann
Stern, Mariana C.
Vega, Ana
Gómez-Caamaño, Antonio
Fachal, Laura
Rosenstein, Barry S.
Kerns, Sarah L.
Ostrer, Harry
Teixeira, Manuel R.
Paulo, Paula
Brandão, Andreia
Watya, Stephen
Lubwama, Alexander
Bensen, Jeanette T.
Fontham, Elizabeth T. H.
Mohler, James
Taylor, Jack A.
Kogevinas, Manolis
Llorca, Javier
Casta�o-Vinyals, Gemma
Cannon-Albright, Lisa A.
Teerlink, Craig C.
Huff, Chad D.
Strom, Sara S.
Multigner, Luc
Blanchet, Pascal
Brureau, Laurent
Kaneva, Radka P.
Slavov, Chavdar
Mitev, Vanio
Leach, Robin J.
Weaver, Brandi
Brenner, Hermann
Cuk, Katarina
Holleczek, Bernd
Saum, Kai-Uwe
Klein, Eric A.
Hsing, Ann W.
Kittles, Rick A.
Murphy, Adam B.
Logothetis, Christopher J.
Kim, Jeri
Neuhausen, Susan L.
Steele, Linda
Ding, Yuan Chun
Isaacs, William B.
Nemesure, Barbara
Hennis, Anselm J. M.
Carpten, John
Pandha, Hardev
Michael, Agnieszka
De Ruyck, Kim
De Meerleer, Gert
Ost, Piet
Xu, Jianfeng
Razack, Azad
Lim, Jasmine
Teo, Soo-Hwang
Newcomb, Lisa F.
Lin, Daniel W.
Fowke, J.
Neslund-Dudas, Christine
Rybicki, Benjamin A.
Gamulin, Marija
Lessel, Davor
Kulis, Tomislav
Usmani, Nawaid
Singhal, Sandeep
Parliament, Matthew
Claessens, Frank
Joniau, Steven
Van den Broeck, Thomas
Gago-Dominguez, Manuela
Castelao, Jose Esteban
Martinez, Maria Elena
Larkin, Samantha
Townsend, Paul A.
Aukim-Hastie, Claire
Bush, W.S.
Aldrich, Melinda C.
Crawford, D.
Srivastava, Shiv
Cullen, Jennifer C.
Petrovics, Gyorgy
Casey, Graham
Roobol, Monique J.
Jenster, Guido
van Schaik, Ron H. N.
Hu, Jennifer J.
Sanderson, Maureen
Varma, Rohit
McKean-Cowdin, Roberta
Torres, Mina
Mancuso, Nicholas
Berndt, S.I.
Van Den Eeden, Stephen K.
Easton, Douglas F.
Chanock, Stephen J.
Cook, Michael B.
Wiklund, Fredrik
Nakagawa, Hidewaki
Witte, John S.
Eeles, Rosalind A.
Kote-Jarai, Zsofia
Haiman, C.
Abstract
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the gRs offering an approach for personalized risk prediction.
Keywords
Date
2021
Type
Journal article
Journal
Nature Genetics
Book
Volume
53
Issue
1
Page Range
65-75
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled