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Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment
Pascoe, Michaela Celeste Howells, David W. Crewther, David P. Constantinou, Nicki Carey, Leeanne M. Rewell, Sarah S. Turchini, Giovanni M. Kaur, Gunveen Crewther, Sheila G.
Pascoe, Michaela Celeste
Howells, David W.
Crewther, David P.
Constantinou, Nicki
Carey, Leeanne M.
Rewell, Sarah S.
Turchini, Giovanni M.
Kaur, Gunveen
Crewther, Sheila G.
Abstract
Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids ( PUFAs ). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.
Keywords
polyunsaturated fatty acids, middle-cerebral-artery-occlusion, mood, stroke
Date
2014
Type
Journal article
Journal
Frontiers in Neurology
Book
Volume
5
Issue
Page Range
1-15
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open
Notes
© 2014 Pascoe, Howells, Crewther, Constantinou, Carey, Rewell, Turchini, Kaur and Crewther. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.