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Resting heart rate and heart rate variability in the year following acute coronary syndrome : How do women fare?
Scovelle, Anna J. Oldenburg, Brian Taylor, C. Barr Hare, David L. Thomas, Emma E. Toukhsati, Samia R. Oldroyd, John Russell, Josephine D. O’Neil, Adrienne
Scovelle, Anna J.
Oldenburg, Brian
Taylor, C. Barr
Hare, David L.
Thomas, Emma E.
Toukhsati, Samia R.
Oldroyd, John
Russell, Josephine D.
O’Neil, Adrienne
Abstract
Background
Women experience poorer health outcomes following acute coronary syndrome (ACS). Heart rate (HR) and heart rate variability (HRV) have emerged as sensitive and cost-effective markers of autonomic function and prognostic risk factors of poor cardiac outcomes. The aim of the current study was to investigate whether sex-specific differences existed across HR and five parameters of HRV, at 1 and 12 months following ACS diagnosis.
Methods
Between January 2013 and June 2014, a sample of 416 ACS patients was enrolled in the Anxiety Depression & Heart Rate Variability in cardiac patients: Evaluating the impact of Negative emotions on functioning after Twenty four months (ADVENT) longitudinal cohort study. At 1 and 12 months following discharge, patient HR and HRV (root mean square of successive differences [RMSDD], standard deviation of RR intervals [SDRR], high frequency power [HF], low frequency power [LF], very low frequency power [VLF]) was measured via three-lead electrocardiogram.
Results
At 1 month post-ACS, sex was a significant predictor of HR and VLF power in fully- adjusted models. At 12 months post-ACS, sex was a predictor of HR, SDRR and VLF power in fully-adjusted models.
Conclusion
Sex-specific differences in resting HR and HRV were observed in the year following ACS, whereby women had higher HR and lower HRV, suggestive of poorer autonomic function. Further large-scale cohort studies examining autonomic function as a driver of sex-specific outcomes following ACS are required.
Keywords
sex, women, acute coronary syndrome, heart rate variability, heart rate
Date
2021
Type
Journal article
Journal
Heart, Lung and Circulation
Book
Volume
30
Issue
1
Page Range
128-134
Article Number
ACU Department
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled