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Protein availability and satellite cell dynamics in skeletal muscle
Shamim, Baubak Hawley, John Camera, Donny
Shamim, Baubak
Hawley, John
Camera, Donny
Abstract
Human skeletal muscle satellite cells are activated in response to both resistance and endurance exercise. It was initially proposed that satellite cell proliferation and differentiation were only required to support resistance exercise-induced hypertrophy. However, satellite cells may also play a role in muscle fibre remodelling after endurance- based exercise and extracellular matrix regulation. Given the importance of dietary protein, particularly branched chain amino acids, in supporting myofibrillar and mitochondrial adaptations to both resistance and endurance- based training, a greater understanding of how protein intake impacts satellite cell activity would provide further insight into the mechanisms governing skeletal muscle remodelling with exercise. While many studies have investigated the capacity for protein ingestion to increase post-exercise rates of muscle protein synthesis, few investigations have examined the role for protein ingestion to modulate satellite cell activity. Here we review the molecular mechanisms controlling the activation of satellite cells in response to mechanical stress and protein intake in both in vitro and in vivo models. We provide a mechanistic framework that describes how protein ingestion may enhance satellite activity and promote exercise adaptations in human skeletal muscle.
Keywords
Date
2018
Type
Journal article
Journal
Sports Medicine
Book
Volume
48
Issue
6
Page Range
1329-1343
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Non-faculty
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Non-faculty
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled