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Acute carbohydrate ingestion does not influence the post-exercise iron-regulatory response in elite keto-adapted race walkers
McKay, Alannah K. A. Peeling, Peter Pyne, David B. Welvaert, Marijke Tee, Nicolin Leckey, Jill J. Sharma, Avish P. Ross, Megan L. R. Garvican-Lewis, Laura A. van Swelm, Rachel P. L.
McKay, Alannah K. A.
Peeling, Peter
Pyne, David B.
Welvaert, Marijke
Tee, Nicolin
Leckey, Jill J.
Sharma, Avish P.
Ross, Megan L. R.
Garvican-Lewis, Laura A.
van Swelm, Rachel P. L.
Abstract
Objectives Adhering to a low carbohydrate (CHO) high fat (LCHF) diet can alter markers of iron metabolism in endurance athletes. This investigation examined the re-introduction of CHO prior to, and during exercise on the iron-regulatory response to exercise in a homogenous (in regard to serum ferritin concentration) group of athletes adapted to a LCHF diet. Design Parallel groups design. Methods Three weeks prior to the exercise trials, twenty-three elite race walkers adhered to either a CHO-rich (n = 14) or LCHF diet (n = 9). A standardised 19–25 km race walk was performed while athletes were still adhering to their allocated dietary intervention (Adapt). A second test was performed three days later, where all athletes were placed on a high CHO diet (CHO Restoration). Venous blood samples were collected pre-, post- and 3 h post-exercise and measured for interleukin-6 (IL-6) and hepcidin-25. Results The post-exercise IL-6 increase was greater in LCHF (p < 0.001) during both the Adapt (LCHF: 13.1-fold increase; 95% CI: 5.6–23.0, CHO: 8.0-fold increase; 5.1–11.1) and CHO Restoration trials (LCHF: 18.5-fold increase; 10.9–28.9, CHO: 6.3-fold increase; 3.9–9.5); outcomes were not different between trials (p = 0.84). Hepcidin-25 concentrations increased 3 h post-exercise (p < 0.001), however, they did not differ between trials (p = 0.46) or diets (p = 0.84). Conclusions The elevated IL-6 response in athletes adapted to a LCHF diet was not attenuated by an acute increase in exogenous CHO availability. Despite diet-induced differences in IL-6 response to exercise, post-exercise hepcidin levels were similar between diets and trials, indicating CHO availability has minimal influence on post-exercise iron metabolism.
Keywords
LCHF diet, iron metabolism, ferritin, hepcidin, interleukin-6, race-walkers
Date
2019
Type
Journal article
Journal
Journal of Science and Medicine in Sport
Book
Volume
22
Issue
6
Page Range
635-640
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled