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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, Mariaelisa Scott, Robert A. Justice, Anne E. Young, Kristin L. Feitosa, Mary F. Barata, Llilda Winkler, Thomas W. Chu, Audrey Y. Mahajan, Anubha Hadley, David
Graff, Mariaelisa
Scott, Robert A.
Justice, Anne E.
Young, Kristin L.
Feitosa, Mary F.
Barata, Llilda
Winkler, Thomas W.
Chu, Audrey Y.
Mahajan, Anubha
Hadley, David
Author
Graff, Mariaelisa
Scott, Robert A.
Justice, Anne E.
Young, Kristin L.
Feitosa, Mary F.
Barata, Llilda
Winkler, Thomas W.
Chu, Audrey Y.
Mahajan, Anubha
Hadley, David
Xue, Luting
Workalemahu, Tsegaselassie
Heard-Costa, Nancy L.
den Hoed, Marcel
Ahluwalia, Tarunveer S.
Qi, bin Qi
Ngwa, Julius S.
Renström, Frida
Quaye, Lydia
Eicher, John D.
Hayes, James E.
Cornelis, Marilyn
Kutalik, Zoltan
Lim, Elise
Luan, Jian'an
Huffman, E.
Zhang, Weihua
Zhao, Wei
Griffin, Paula J.
Lorentzon, Mattias
Scott, Robert A.
Justice, Anne E.
Young, Kristin L.
Feitosa, Mary F.
Barata, Llilda
Winkler, Thomas W.
Chu, Audrey Y.
Mahajan, Anubha
Hadley, David
Xue, Luting
Workalemahu, Tsegaselassie
Heard-Costa, Nancy L.
den Hoed, Marcel
Ahluwalia, Tarunveer S.
Qi, bin Qi
Ngwa, Julius S.
Renström, Frida
Quaye, Lydia
Eicher, John D.
Hayes, James E.
Cornelis, Marilyn
Kutalik, Zoltan
Lim, Elise
Luan, Jian'an
Huffman, E.
Zhang, Weihua
Zhao, Wei
Griffin, Paula J.
Lorentzon, Mattias
Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Keywords
Date
2017
Type
Journal article
Journal
PLoS Genetics
Book
Volume
13
Issue
4
Page Range
1-26
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open
Notes
The work is made available under the Creative Commons CC0 public domain dedication.