Oxidative stress in surgery
Rosenfeldt, Franklin Wilson, Mark Lee, Geraldine Kure, Christina Ou, Ruchong Braun, Lesley de Haan, Judy
Rosenfeldt, Franklin
Wilson, Mark
Lee, Geraldine
Kure, Christina
Ou, Ruchong
Braun, Lesley
de Haan, Judy
Abstract
Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.
Keywords
antioxidant capacity, free radicals, oxidative stress, reactive oxygen species, surgery
Date
2014
Type
Book chapter
Journal
Book
Systems biology of free radicals and antioxidants
Volume
Issue
Page Range
3929-3946