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Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Levinger, Itamar Scott, David Nicholson, Geoffrey Stuart, Amanda Duque, Gustavo McCorquodale, Thomas Herrmann, Markus Ebeling, Peter Sanders, Kerrie
Levinger, Itamar
Scott, David
Nicholson, Geoffrey
Stuart, Amanda
Duque, Gustavo
McCorquodale, Thomas
Herrmann, Markus
Ebeling, Peter
Sanders, Kerrie
Abstract
We investigated the association between undercarboxylated osteocalcin (ucOC) and lower-limb muscle strength in women over the age of 70 years. The study also aims to confirm the association between bone turnover markers and heel ultrasound measures. A post-hoc analysis using data collected as part of a randomized placebo-controlled trial of vitamin D supplementation. An immunoassay was used to quantify total OC (tOC), with hydroxyapatite pre-treatment for ucOC. We determined associations of absolute and relative (ucOC/tOC; ucOC%) measures of ucOC with lower-limb muscle strength, heel ultrasound measures of speed of sound (SOS) and broadband ultrasound attenuation (BUA), bone turnover markers (BTMs; P1NP and CTx) and the acute phase protein alpha-1-antichymotrypsin (α-ACT). ucOC%, but not absolute ucOC concentration, was positively associated with hip flexor, hip abductor and quadriceps muscle strength (all p < 0.05). ucOC% was negatively associated with α-ACT (β-coefficient = − 0.24, p = 0.02). tOC was positively associated with both P1NP and CTx (p < 0.001). For each per unit increase in tOC (μg/L) there was a corresponding lower BUA, SOS and SI (β-coefficient = − 0.28; − 0.23 and − 0.23, respectively; all p < 0.04). In conclusion, ucOC% is positively associated with muscle strength and negatively associated with α-ACT. These data support a role for ucOC in musculoskeletal interactions in humans. Whilst tOC is associated with bone health, ucOC% and ucOC may also be linked to falls and fracture risk by influencing muscle function.
Keywords
Date
2014
Type
Journal article
Journal
Bone
Book
Volume
64
Issue
Page Range
8-12
Article Number
ACU Department
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Event URL
Open Access Status
License
File Access
Controlled