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Protein intake at breakfast promotes a positive whole-body protein balance in a dose-response manner in healthy children : A randomized trial
Karagounis, Leonidas G. Volterman, Kimberly A. Breuillé, Denis Offord, Elizabeth A. Emady-Azar, Shahram Moore, Daniel R.
Karagounis, Leonidas G.
Volterman, Kimberly A.
Breuillé, Denis
Offord, Elizabeth A.
Emady-Azar, Shahram
Moore, Daniel R.
Abstract
Background
Protein ingestion promotes whole-body net protein balance (NB) in children, which is a prerequisite for growth. Determining how much protein is required at breakfast to promote a positive NB, which may be negative after the traditional overnight fast in children, has yet to be determined.
Objective
We determined the impact of incremental doses of milk protein at breakfast as well as the impact of daily dietary protein distribution on NB in children.
Methods
A total of 28 children [14 boys, 14 girls; age range: 7–11 y; body mass index (mean ± SD, in kg/m2): 16.0 ± 1.9] completed 2 intervention trials. During the breakfast meal, participants consumed an isoenergetic beverage with different amounts of protein (0, 7, 14, or 21 g for Groups A–D, respectively) and [15N]-glycine to measure whole body protein metabolism. Whole-body nitrogen turnover, protein synthesis (PS), protein breakdown, and NB were measured over 9 and 24 h.
Results
Following an overnight fast, children were in negative NB (–64.5 mg · kg−1 · h−1). Protein ingestion at breakfast induced a stepwise increase in NB over 9 h [Groups A (6.2 mg · kg−1 · h−1) < B (27.9 mg · kg−1 · h−1) < C (46.9 mg · kg−1 · h−1) < D (66.0 mg · kg−1 · h−1)] with all conditions different from each other (all P < 0.01). PS was 42% greater in Group D than in Group A over 9 h (P < 0.05).
Conclusions
Consuming ≥7 g of the total daily protein intake at breakfast attenuates the observed overnight protein losses in children during the subsequent 9 h following breakfast consumption. The dose-dependent increase in NB over a daytime fed period, inclusive of breakfast and lunch, highlights the importance of breakfast protein intake on acute anabolism in healthy active children. This trial was registered at clinicaltrials.gov as NCT02465151.
Keywords
children, breakfast, protein distribution, protein timing, growth
Date
2018
Type
Journal article
Journal
The Journal of Nutrition
Book
Volume
148
Issue
5
Page Range
729-737
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC 4.0
File Access
Open