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A parietal biomarker for ADHD liability : As predicted by the distributed effects perspective model of ADHD
Sigi Hale, T Wiley, Joshua Smalley, Susan Tung, Kelly Kaminsky, Olivia McGough, James Jaini, Ashwin Loo, Sandra
Sigi Hale, T
Wiley, Joshua
Smalley, Susan
Tung, Kelly
Kaminsky, Olivia
McGough, James
Jaini, Ashwin
Loo, Sandra
Abstract
Background: We previously hypothesized that poor task-directed sensory information processing should be indexed by increased weighting of right hemisphere (RH) biased attention and visuo-perceptual brain functions during task operations and have demonstrated this phenotype in ADHD across multiple studies, using multiple methodologies. However, in our recent distributed effects model of ADHD, we surmised that this phenotype is not ADHD specific, but rather more broadly reflective of any circumstance that disrupts the induction and maintenance of an emergent task-directed neural architecture. Under this view, increased weighting of RH-biased attention and visuo-perceptual brain functions is expected to generally index neurocognitive sets that are not optimized for task-directed thought and action, and when durable expressed, liability for ADHD.
Method: The current study tested this view by examining whether previously identified rightward parietal EEG asymmetry in ADHD was associated with common ADHD characteristics and comorbidities [i.e., ADHD risk factors (RFs)].
Results: Barring one exception (non-right handedness), we found that it was. Rightward parietal asymmetry (RPA) was associated with carrying the DRD4-7R risk allele, being male, having mood disorder, and having anxiety disorder. However, differences in the specific expression of RPA were observed, which are discussed in relation to possible unique mechanisms underlying ADHD liability in different ADHD RFs.
Conclusion: Rightward parietal asymmetry appears to be a durable feature of ADHD liability, as predicted by the Distributed Effects Perspective Model of ADHD. Moreover, variability in the expression of this phenotype may shed light on different sources of ADHD liability.
Keywords
attention, ADHD, laterality, asymmetry, parietal, risk factors, liability, DRD4
Date
2015
Type
Journal article
Journal
Frontiers in Psychiatry
Book
Volume
6
Issue
63
Page Range
1-19
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
CC BY 4.0
File Access
Open