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The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial
Thorsen, Ida K. Johansen, Mette Y. Pilmark, Nanna S. Jespersen, Naja Z. Brinkløv, Cecilie F. Benatti, Fabiana B. Dunstan, David W. Karstoft, Kristian Pedersen, Bente K. Ried-Larsen, Mathias
Thorsen, Ida K.
Johansen, Mette Y.
Pilmark, Nanna S.
Jespersen, Naja Z.
Brinkløv, Cecilie F.
Benatti, Fabiana B.
Dunstan, David W.
Karstoft, Kristian
Pedersen, Bente K.
Ried-Larsen, Mathias
Abstract
Objective The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure. Materials/Methods Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m2; VO2max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4% (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (~30% of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and 4 h into the intervention (total of 2310 ± 247 kcal; 50% energy from carbohydrate, 50% energy from fat). Outcomes included the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT. Results No difference [95% CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT (−65.3 mmol/l∗min [−256.3; 125.7], +53.8 mmol/l∗min [−143.1; 250.8], and +18.6 mmol/l∗min [−172.4; 209.6], respectively). Conclusions Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.
Keywords
sedentary behavior, walking, cardiometabolic risk, postprandial glucose metabolism, postprandial lipid metabolism, substrate oxidation
Date
2019
Type
Journal article
Journal
Metabolism: Clinical and experimental
Book
Volume
96
Issue
Page Range
1-7
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled