Loading...
Road to full recovery: Longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years
Alvarez-Jimenez, Mario Gleeson, John Henry, L. Harrigan, Susan Harris, M. Killackey, Eoin Bendall, Sarah Amminger, G. Yung, Alison Herrman, H.
Alvarez-Jimenez, Mario
Gleeson, John
Henry, L.
Harrigan, Susan
Harris, M.
Killackey, Eoin
Bendall, Sarah
Amminger, G.
Yung, Alison
Herrman, H.
Abstract
Background: In recent years there has been increasing interest in functional recovery in the early phase of schizophrenia. Concurrently, new remission criteria have been proposed and several studies have examined their clinical relevance for prediction of functional outcome in first-episode psychosis (FEP). However, the longitudinal interrelationship between full functional recovery (FFR) and symptom remission has not yet been investigated. This study sought to: (1) examine the relationships between FFR and symptom remission in FEP over 7.5 years; (2) test two different models of the interaction between both variables.
Method: Altogether, 209 FEP patients treated at a specialized early psychosis service were assessed at baseline, 8 months, 14 months and 7.5 years to determine their remission of positive and negative symptoms and functional recovery. Multivariate logistic regression and path analysis were employed to test the hypothesized relationships between symptom remission and FFR.
Results: Remission of both positive and negative symptoms at 8-month follow-up predicted functional recovery at 14-month follow-up, but had limited value for the prediction of FFR at 7.5 years. Functional recovery at 14-month follow-up significantly predicted both FFR and remission of negative symptoms at 7.5 years, irrespective of whether remission criteria were simultaneously met. The association remained significant after controlling for baseline prognostic indicators.
Conclusions: These findings provided support for the hypothesis that early functional and vocational recovery plays a pivotal role in preventing the development of chronic negative symptoms and disability. This underlines the need for interventions that specifically address early psychosocial recovery.
Keywords
Date
2012
Type
Journal article
Journal
Psychological Medicine
Book
Volume
42
Issue
3
Page Range
595-606
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
School of Education
Faculty of Education and Arts
Faculty of Health Sciences
School of Education
Faculty of Education and Arts
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled