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The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment
Lamon, Séverine Morabito, Aimee Arentson-Lantz, Emily Knowles, Olivia Vincent, Grace Elizabeth Condo, Dominique Alexander, Sarah Elizabeth Garnham, Andrew Paddon-Jones, Douglas Aisbett, Brad
Lamon, Séverine
Morabito, Aimee
Arentson-Lantz, Emily
Knowles, Olivia
Vincent, Grace Elizabeth
Condo, Dominique
Alexander, Sarah Elizabeth
Garnham, Andrew
Paddon-Jones, Douglas
Aisbett, Brad
Abstract
Chronic sleep loss is a potent catabolic stressor, increasing the risk of metabolic dysfunction and loss of muscle mass and function. To provide mechanistic insight into these clinical outcomes, we sought to determine if acute sleep deprivation blunts skeletal muscle protein synthesis and promotes a catabolic environment. Healthy young adults (N = 13; seven male, six female) were subjected to one night of total sleep deprivation (DEP) and normal sleep (CON) in a randomized cross-over design. Anabolic and catabolic hormonal profiles were assessed across the following day. Postprandial muscle protein fractional synthesis rate (FSR) was assessed between 13:00 and 15:00 and gene markers of muscle protein degradation were assessed at 13:00. Acute sleep deprivation reduced muscle protein synthesis by 18% (CON: 0.072 ± 0.015% vs. DEP: 0.059 ± 0.014%·h-1, p = .040). In addition, sleep deprivation increased plasma cortisol by 21% (p = .030) and decreased plasma testosterone by 24% (p = .029). No difference was found in the markers of protein degradation. A single night of total sleep deprivation is sufficient to induce anabolic resistance and a procatabolic environment. These acute changes may represent mechanistic precursors driving the metabolic dysfunction and body composition changes associated with chronic sleep deprivation.
Keywords
hormones, muscle, muscle protein synthesis, sleep deprivation
Date
2021
Type
Journal article
Journal
Physiological Reports
Book
Volume
9
Issue
1
Page Range
1-13
Article Number
Article e14660
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY
File Access
Open