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Impact of dementia and mild cognitive impairment on bone health in older people
Curtis, Elizabeth M. Miguel, Mario McEvoy, Claire Ticinesi, Andrea Torre, Carla Al-Daghri, Nasser Alokail, Majed Bałkowiec-Iskra, Ewa Bruyère, Olivier Burlet, Nansa
Curtis, Elizabeth M.
Miguel, Mario
McEvoy, Claire
Ticinesi, Andrea
Torre, Carla
Al-Daghri, Nasser
Alokail, Majed
Bałkowiec-Iskra, Ewa
Bruyère, Olivier
Burlet, Nansa
Author
Curtis, Elizabeth M.
Miguel, Mario
McEvoy, Claire
Ticinesi, Andrea
Torre, Carla
Al-Daghri, Nasser
Alokail, Majed
Bałkowiec-Iskra, Ewa
Bruyère, Olivier
Burlet, Nansa
Cavalier, Etienne
Cerreta, Francesca
Clark, Patricia
Cherubini, Antonio
Cooper, Cyrus
D’Amelio, Patrizia
Fuggle, Nicholas
Gregson, Celia
Halbout, Philippe
Kanis, John A.
Kaufman, Jean
Laslop, Andrea
Maggi, Stefania
Maier, Andrea
Matijevic, Radmila
McCloskey, Eugene
Ormarsdottir, Sif
Yerro, Concha Prieto
Radermecker, Régis P.
Rolland, Yves
Singer, Andrea
Veronese, Nicola
Rizzoli, René
Reginster, Jean Yves
Harvey, Nicholas C.
Miguel, Mario
McEvoy, Claire
Ticinesi, Andrea
Torre, Carla
Al-Daghri, Nasser
Alokail, Majed
Bałkowiec-Iskra, Ewa
Bruyère, Olivier
Burlet, Nansa
Cavalier, Etienne
Cerreta, Francesca
Clark, Patricia
Cherubini, Antonio
Cooper, Cyrus
D’Amelio, Patrizia
Fuggle, Nicholas
Gregson, Celia
Halbout, Philippe
Kanis, John A.
Kaufman, Jean
Laslop, Andrea
Maggi, Stefania
Maier, Andrea
Matijevic, Radmila
McCloskey, Eugene
Ormarsdottir, Sif
Yerro, Concha Prieto
Radermecker, Régis P.
Rolland, Yves
Singer, Andrea
Veronese, Nicola
Rizzoli, René
Reginster, Jean Yves
Harvey, Nicholas C.
Abstract
Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly ageing global population, are increasing in prevalence. These conditions are closely associated, with shared risk factors, common underlying biological mechanisms and potential direct causal pathways. In this review, the epidemiological and mechanistic links between mild cognitive impairment, dementia and skeletal health are explored. Discussion will focus on how changes in brain and bone signalling can underly associations between these conditions, and will consider the molecular and cellular drivers in the context of inflammation and the gut microbiome. There is a complex interplay between nutritional changes, which may precede or follow the onset of mild cognitive impairment (MCI) or dementia, and bone health. Polypharmacy is common in patients with MCI or dementia, and there are difficult prescribing decisions to be made due to the elevated risk of falls associated with many drugs used for associated problems, which can consequently increase fracture risk. Some medications prescribed for cognitive impairment may directly impact bone health. In addition, patients may have difficulty remembering medication without assistance, meaning that osteoporosis drugs may be prescribed but not taken. Cognitive impairment may be improved or delayed by physical activity and exercise, and there is evidence for the additional benefits of physical activity on falls and fractures. Research gaps and priorities with the aim of reducing the burden of osteoporosis and fractures in people with MCI or dementia will also be discussed.
Keywords
osteoporosis, epidemiology, cognitive impairment, dementia, bone mineral density, fracture
Date
2025
Type
Journal article
Journal
Aging Clinical and Experimental Research
Book
Volume
37
Issue
1
Page Range
1-22
Article Number
Article 5
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open
Notes
© The Author(s) 2024.
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