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Dietary patterns and β-amyloid deposition in aging Australian women
Hill, Edward Clifton, Peter Goodwill, Alicia M. Dennerstein, Lorraine Campbell, Stephen Szoeke, Cassandra
Hill, Edward
Clifton, Peter
Goodwill, Alicia M.
Dennerstein, Lorraine
Campbell, Stephen
Szoeke, Cassandra
Abstract
Introduction
Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid‐β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.
Methods
Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F‐18 florbetaben positron emission tomography scanning.
Results
Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).
Discussion
This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.
Keywords
biomarkers, Alzheimer’s disease, neuropathology, b-amyloid protein, diet, nutrition, dietary pattern, factor analysis, women
Date
2018
Type
Journal article
Journal
Alzheimer's and Dementia: Translational Research and Clinical Interventions
Book
Volume
4
Issue
1
Page Range
535-541
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open