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Diabetes mellitus increases risk of incident dementia in APOE 4 carriers : A meta-analysis
Li, Lily Cavuoto, Marina Biddiscombe, Karen Pike, Kerryn E.
Li, Lily
Cavuoto, Marina
Biddiscombe, Karen
Pike, Kerryn E.
Abstract
Background:Dementia is a devastating condition for older adults, with both modifiable (e.g., diabetes mellitus) and unmodifiable risk factors (e.g., APOE ɛ4 allele). It remains unclear how, and to what extent, diabetes impacts dementia risk via both cerebrovascular and amyloid-β pathways. Objective:We conducted a quantitative meta-analysis to investigate the contribution of diabetes to incident dementia risk in people with ɛ4 and, based on the vascular-related neuropathology of diabetes, whether the combination of these factors increases risk for vascular dementia versus Alzheimer’s disease (AD). Methods:Systematic literature searches were conducted using EMBASE, MEDLINE, PsycINFO, and CINAHL databases. Pooled relative risk (RR) estimates were calculated using a random effects model, and subgroup analyses conducted across dementia subtypes. Results:Twelve studies were included, with a total of 16,200 participants. Considered concurrently, diabetes increased incident dementia risk an additional 35% for those with ɛ4 (RR = 1.35, 95% CI = 1.13–1.63). Similar patterns were observed for AD and vascular dementia. Conclusion:Interventions to prevent co-morbid diabetes, and diabetes-related complications and neuropathological changes, may be one way of modifying dementia risk in the vulnerable ɛ4 population.
Keywords
Alzheimer’s disease, Apolipoproteins E, dementia, diabetes mellitus, risk factors, vascular dementia
Date
2020
Type
Journal article
Journal
Journal of Alzheimer's Disease
Book
Volume
74
Issue
4
Page Range
1295-1308
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled