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Physical activity is associated with attenuated disease progression in Chronic Obstructive Disease
Demeyer, Heleen Donaire-Gonzalez, David Gimeno-Santos, Elena Ramon, Maria A. de Battle, Jordie Benet, Marta Serra, Ignasi Guerra, Stefano Farrero, Eva Rodriguez, Esther
Demeyer, Heleen
Donaire-Gonzalez, David
Gimeno-Santos, Elena
Ramon, Maria A.
de Battle, Jordie
Benet, Marta
Serra, Ignasi
Guerra, Stefano
Farrero, Eva
Rodriguez, Esther
Author
Demeyer, Heleen
Donaire-Gonzalez, David
Gimeno-Santos, Elena
Ramon, Maria A.
de Battle, Jordie
Benet, Marta
Serra, Ignasi
Guerra, Stefano
Farrero, Eva
Rodriguez, Esther
Ferrer, Jaume
Sauleda, Jaume
Monso, Eduard
Gea, Joaquim
Rodriguez-Roisin, Robert
Agusti, Alvar
Antó, Josep M.
Garcia-Aymerich, Judith
Donaire-Gonzalez, David
Gimeno-Santos, Elena
Ramon, Maria A.
de Battle, Jordie
Benet, Marta
Serra, Ignasi
Guerra, Stefano
Farrero, Eva
Rodriguez, Esther
Ferrer, Jaume
Sauleda, Jaume
Monso, Eduard
Gea, Joaquim
Rodriguez-Roisin, Robert
Agusti, Alvar
Antó, Josep M.
Garcia-Aymerich, Judith
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. Methods: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. Results: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL[middle dot]min-1[middle dot]mm Hg-1 less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. Conclusions: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPD patients.
Keywords
longitudinal analysis, lung function, muscle strength, health status, exercise capacity
Date
2019
Type
Journal article
Journal
Medicine and Science in Sports and Exercise
Book
Volume
51
Issue
5
Page Range
833-840
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as green open access
License
File Access
Controlled
Open
Open