Langendorf, Christopher G.Scott, John W.Kemp, Bruce E.2025-10-1720172451-945610.1016/j.chembiol.2017.07.005https://hdl.handle.net/20.500.14802/25128Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal a novel off-target mechanism where the Src kinase inhibitor SU6656 paradoxically primes AMPK for phosphorylation and activation by the upstream kinase LKB1.Journal article2-s2.0-85024884849Controlled201048474