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Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers
Casas, M. Nieuwenhuijsen, Mark Martínez, David Ballester, Ferran Basagaña, Xavier Basterrechea, M. Chatzi, Leda Chevrier, Cécile Eggesbø, Merete Fernández, Mariana F.
Casas, M.
Nieuwenhuijsen, Mark
Martínez, David
Ballester, Ferran
Basagaña, Xavier
Basterrechea, M.
Chatzi, Leda
Chevrier, Cécile
Eggesbø, Merete
Fernández, Mariana F.
Author
Casas, M.
Nieuwenhuijsen, Mark
Martínez, David
Ballester, Ferran
Basagaña, Xavier
Basterrechea, M.
Chatzi, Leda
Chevrier, Cécile
Eggesbø, Merete
Fernández, Mariana F.
Govarts, Eva
Guxens, Mònica
Grimalt, Joan O.
Hertz-Picciotto, Irva
Iszatt, Nina
Kasper-Sonnenberg, Monika
Kiviranta, Hannu
Kogevinas, Manolis
Palkovicova, Lubica
Ranft, Ulrich
Schoeters, Greet
Patelarou, Evridiki
Petersen, Maria Skaalum
Torrent, M.
Trnovec, Tomas
Valvi, Damaskini
Toft, Gunnar Vase
Weihe, Pál
Weisglas-Kuperus, Nynke
Wilhelm, Michael
Wittsiepe, Jürgen
Vrijheid, Martine
Bonde, Jens Peter
Nieuwenhuijsen, Mark
Martínez, David
Ballester, Ferran
Basagaña, Xavier
Basterrechea, M.
Chatzi, Leda
Chevrier, Cécile
Eggesbø, Merete
Fernández, Mariana F.
Govarts, Eva
Guxens, Mònica
Grimalt, Joan O.
Hertz-Picciotto, Irva
Iszatt, Nina
Kasper-Sonnenberg, Monika
Kiviranta, Hannu
Kogevinas, Manolis
Palkovicova, Lubica
Ranft, Ulrich
Schoeters, Greet
Patelarou, Evridiki
Petersen, Maria Skaalum
Torrent, M.
Trnovec, Tomas
Valvi, Damaskini
Toft, Gunnar Vase
Weihe, Pál
Weisglas-Kuperus, Nynke
Wilhelm, Michael
Wittsiepe, Jürgen
Vrijheid, Martine
Bonde, Jens Peter
Abstract
Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p′-DDE) can impair fetal growth; however, the exposure–response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure–response relationship between PCB-153 and p-p′-DDE and birth outcomes; to evaluate whether any no exposure–effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother–child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure–response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194 g (95% CI − 314, − 74) per 1 μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure–response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.
Keywords
Biomarkers of exposure, Persistent organic pollutants, Polychlorinated biphenyls (PCBs), Dichlorodiphenyldichloroethylene (DDE), Birth weight
Date
2015
Type
Journal article
Journal
Environment International
Book
Volume
74
Issue
Page Range
23-31
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open