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Patterns of medication prescription by dementia diagnosis in Australian nursing home residents: A cross-sectional study
Liu, Enwu Dyer, Suzanne M. Whitehead, Craig O'Donnell, Lisa Kouladjian Gnanamanickam, Emmanuel S. Harrison, Stephanie L. Milte, Rachel Crotty, Maria
Liu, Enwu
Dyer, Suzanne M.
Whitehead, Craig
O'Donnell, Lisa Kouladjian
Gnanamanickam, Emmanuel S.
Harrison, Stephanie L.
Milte, Rachel
Crotty, Maria
Abstract
Background Current information on the patterns of medication use in nursing home residents living with dementia is conflicting. Aim The aim of this study was to investigate medication use and its associations with dementia diagnosis in Australian nursing home residents. Methods A cross‐sectional study of 541 residents from 17 Australian nursing homes was performed. Results Over 12 months, nursing home residents were prescribed a mean (±SD) of 14.5 ± 6.8 medications each. Approximately 95% of residents were prescribed medications for the nervous system, and 94% were prescribed medications for the alimentary tract and metabolism. After adjustment for potential confounders, those with dementia were less likely to be prescribed medications for the cardiovascular system (odds ratio (OR) 0.45, 95% confidence interval (CI) 0.27–0.77, p = 0.0032) and respiratory system (OR 0.38, 95% CI: 0.25–0.60, p < 0.0001). Further analysis of specific medications showed that residents with dementia were more likely to be prescribed risperidone (OR: 9.38, 95% CI: 4.01–21.94, p < 0.0001), buprenorphine (OR 3.37, 95% CI: 1.78–6.36, p = 0.0002) and trimethoprim (OR 1.78, 95% CI: 1.06–2.97, p = 0.0282), but less likely to be prescribed glyceryl trinitrate (OR 0.42, 95% CI: 0.19–0.94, p = 0.0340) and salbutamol (OR 0.34, 95% CI: 0.2–0.6, p = 0.0002) in addition to other specific medications. Conclusions Increased awareness of possible undertreatment of cardiovascular and respiratory conditions, and possible overtreatment of urinary tract infection, in those living with dementia in nursing home settings may improve management of this vulnerable population.
Keywords
prescribed medicines, dementia, residential facilities, nursing home, aged
Date
2019
Type
Journal article
Journal
Journal of Pharmacy Practice and Research
Book
Volume
49
Issue
1
Page Range
33-40
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled