Loading...
Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: Strategies for evaluation and prevention
Wijck, Kim Van Lenaerts, Kaatje Grootjans, Joep Wijnands, Karolina A. P. Poeze, Martijn Van Loon, Luc J. C. Dejong, Cornelis H. C. Buurman, Wim A.
Wijck, Kim Van
Lenaerts, Kaatje
Grootjans, Joep
Wijnands, Karolina A. P.
Poeze, Martijn
Van Loon, Luc J. C.
Dejong, Cornelis H. C.
Buurman, Wim A.
Abstract
Physical exercise places high demands on the adaptive capacity of the human body. Strenuous physical performance increases the blood supply to active muscles, cardiopulmonary system, and skin to meet the altered demands for oxygen and nutrients. The redistribution of blood flow, necessary for such an increased blood supply to the periphery, significantly reduces blood flow to the gut, leading to hypoperfusion and gastrointestinal ( GI ) compromise. A compromised GI system can have a negative impact on exercise performance and subsequent postexercise recovery due to abdominal distress and impairments in the uptake of fluid, electrolytes, and nutrients. In addition, strenuous physical exercise leads to loss of epithelial integrity, which may give rise to increased intestinal permeability with bacterial translocation and inflammation. Ultimately, these effects can deteriorate postexercise recovery and disrupt exercise training routine. This review provides an overview on the recent advances in our understanding of GI physiology and pathophysiology in relation to strenuous exercise. Various approaches to determine the impact of exercise on the individual athlete's GI tract are discussed. In addition, we elaborate on several promising components that could be exploited for preventive interventions.
Keywords
Date
2012
Type
Journal article
Journal
American Journal of Physiology - Gastrointestinal and Liver Physiology
Book
Volume
303
Issue
2
Page Range
155-168
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled