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A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: Protocol and rationale of the Take a STAND for Health study
Ana Jessica Pinto Tiago Peçanha Kamila Meireles Fabiana Braga Benatti Karina Bonfiglioli Ana Lúcia De Sá Pinto Fernanda Rodrigues Lima Rosa M.R. Pereira Maria Claudia Costa Irigoyen James Edward Turner
Ana Jessica Pinto
Tiago Peçanha
Kamila Meireles
Fabiana Braga Benatti
Karina Bonfiglioli
Ana Lúcia De Sá Pinto
Fernanda Rodrigues Lima
Rosa M.R. Pereira
Maria Claudia Costa Irigoyen
James Edward Turner
Abstract
Background
Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis.
Methods
The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches.
Discussion
Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis.
Keywords
sitting, light-intensity physical activity, rheumatic arthritis
Date
2020
Type
Journal article
Journal
Trials
Book
Volume
21
Issue
Page Range
1-13
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open