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Physiologic assessment of lung growth and development throughout infancy and childhood
Gibson, Ann-Marie Ranganathan, Sarath Doyle, Lex W.
Gibson, Ann-Marie
Ranganathan, Sarath
Doyle, Lex W.
Abstract
Several lung function tests may be used for the physiologic assessment of lung growth and development throughout infancy and childhood. Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age have been recently reported, and studies where infant and preschool lung function has been applied in these specific respiratory disorders have been reviewed. Normal reference ranges for older subjects, including into adulthood, have also been reported.
When interpreting physiologic measures of lung growth and development throughout infancy and childhood, it is important to be aware of the influence of growth and maturity, the influence of demographic factors such as sex and ethnicity, the normal intra- and interindividual variability of the parameters at each age, and the diagnostic value of each of the parameters obtained in each test.
Very preterm (< 32 weeks gestational age) or very low birth weight (<1500 g birth weight) survivors, particularly those who had bronchopulmonary dysplasia in the newborn period, have more lung function abnormalities, particularly airway obstruction, than do term-born survivors and are at high risk of adult obstructive lung disease as they grow older.
Keywords
airway obstruction, bronchopulmonary dysplasia, lung diffusion capacity, lung function, very preterm, very low birth weight
Date
2016
Type
Book chapter
Journal
Book
Fetal and neonatal lung development : Clinical correlates and technologies for the future
Volume
Issue
Page Range
253-268
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled