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Resting state functional connectivity in adolescent synthetic cannabinoid users with and without attention-deficit/hyperactivity disorder
Yüncü, Zeki Cakmak Celik, Zehra Colak, Ciğdem Thapa, Tribikram Fornito, Alex Bora, Emre Kitis, Omer Zorlu, Nabi
Yüncü, Zeki
Cakmak Celik, Zehra
Colak, Ciğdem
Thapa, Tribikram
Fornito, Alex
Bora, Emre
Kitis, Omer
Zorlu, Nabi
Abstract
Objective
Synthetic cannabinoids (SCs) have become increasingly popular in recent years, especially among adolescents. The first aim of the current study was to examine resting-state functional connectivity (rsFC) in SC users compared to controls. Our second aim was to examine the influence of comorbid attention-deficit/hyperactivity disorder (ADHD) symptomatology on rsFC changes in SC users compared to controls.
Methods
Resting-state functional magnetic resonance imaging (fMRI) analysis included 25 SC users (14 without ADHD and 11 with ADHD combined type) and 12 control subjects.
Results
We found (i) higher rsFC between the default mode network (DMN) and salience network, dorsal attention network and cingulo-opercular network, and (ii) lower rsFC within the DMN and between the DMN and visual network in SC users compared to controls. There were no significant differences between SC users with ADHD and controls, nor were there any significant differences between SC users with and without ADHD.
Conclusions
We found the first evidence of abnormalities within and between resting state networks in adolescent SC users without ADHD. In contrast, SC users with ADHD showed no differences compared to controls. These results suggest that comorbidity of ADHD and substance dependence may show different rsFC alterations than substance use alone.
Keywords
ADHD, connectomics, functional connectivity, synthetic cannabinoids
Date
2021
Type
Journal article
Journal
Human Psychopharmacology
Book
Volume
36
Issue
5
Page Range
1-8
Article Number
Article e2781
ACU Department
School of Allied Health
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
DOI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled