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Altering the course of schizophrenia: Progress and perspectives
Millan, Mark J. Andrieux, Annie Bartzokis, George Cadenhead, Kristin Dazzan, Paola Fusar-Poli, Paolo Gallinat, Jürgen Giedd, Jay Grayson, Dennis R. Heinrichs, Markus
Millan, Mark J.
Andrieux, Annie
Bartzokis, George
Cadenhead, Kristin
Dazzan, Paola
Fusar-Poli, Paolo
Gallinat, Jürgen
Giedd, Jay
Grayson, Dennis R.
Heinrichs, Markus
Author
Millan, Mark J.
Andrieux, Annie
Bartzokis, George
Cadenhead, Kristin
Dazzan, Paola
Fusar-Poli, Paolo
Gallinat, Jürgen
Giedd, Jay
Grayson, Dennis R.
Heinrichs, Markus
Kahn, René
Krebs, Marie-Odile
Leboyer, Marion
Lewis, David
Marin, Oscar
Marin, Philippe
Meyer-Lindenberg, Andreas
McGorry, Patrick
McGuire, Paul K.
Owen, Michael J.
Patterson, Paul
Sawa, Akira
Spedding, Michael
Uhlhaas, Peter
Vaccarino, Flora
Wahlestedt, Claes
Weinberger, Daniel
Andrieux, Annie
Bartzokis, George
Cadenhead, Kristin
Dazzan, Paola
Fusar-Poli, Paolo
Gallinat, Jürgen
Giedd, Jay
Grayson, Dennis R.
Heinrichs, Markus
Kahn, René
Krebs, Marie-Odile
Leboyer, Marion
Lewis, David
Marin, Oscar
Marin, Philippe
Meyer-Lindenberg, Andreas
McGorry, Patrick
McGuire, Paul K.
Owen, Michael J.
Patterson, Paul
Sawa, Akira
Spedding, Michael
Uhlhaas, Peter
Vaccarino, Flora
Wahlestedt, Claes
Weinberger, Daniel
Abstract
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to -- and of -- this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.
Keywords
Date
2016
Type
Journal article
Journal
Nature Reviews Drug Discovery
Book
Volume
15
Issue
7
Page Range
485-515
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled