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Fake inhibitors: AMPK activation trumps inhibition
Langendorf, Christopher G. Scott, John W. Kemp, Bruce E.
Langendorf, Christopher G.
Scott, John W.
Kemp, Bruce E.
Abstract
Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal a novel off-target mechanism where the Src kinase inhibitor SU6656 paradoxically primes AMPK for phosphorylation and activation by the upstream kinase LKB1.
Keywords
Date
2017
Type
Journal article
Journal
Cell Chemical Biology
Book
Volume
24
Issue
7
Page Range
775-777
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled