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Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage
Petersen, Bibi Wulf, Hans C. Triguero-Mas, Margarita Philipsen, Peter A. Thieden, Elisabeth Olsen, Peter Heydenreich, Jakob Dadvand, Payam Basagaña, Xavier Liljendahl, Tove S.
Petersen, Bibi
Wulf, Hans C.
Triguero-Mas, Margarita
Philipsen, Peter A.
Thieden, Elisabeth
Olsen, Peter
Heydenreich, Jakob
Dadvand, Payam
Basagaña, Xavier
Liljendahl, Tove S.
Abstract
Skin cancer is caused by solar UVR, which is also essential for vitamin D production. DNA damage (thymine dimers: T-T dimers) and vitamin D (25(OH)D) synthesis are both initiated by solar UVB. We aimed to investigate the simultaneous adverse and beneficial effects of solar UVB exposure in holidaymakers. Sun-seekers and skiers (n=71) were observed over 6 days through on-site monitoring, personal diary entries, and recording of personal UVB exposure doses with electronic dosimeters. Urine and blood samples were analyzed for T-T dimers and 25(OH)D, respectively. The volunteers had a statistically significant increase in vitamin D. There were strong associations between UVB exposure and post-holiday levels of T-T dimers and vitamin D, as well as between post-holiday T-T dimers and vitamin D. We conclude that UVB-induced vitamin D synthesis is associated with considerable DNA damage in the skin. These data, on two major health predictors, provide a basis for further field studies that may result in better understanding of the risks and benefits of “real life” solar exposure. However, vitamin D status can be improved more safely through the use of vitamin D dietary supplements.
Keywords
Date
2014
Type
Journal article
Journal
Journal of Investigative Dermatology
Book
Volume
134
Issue
11
Page Range
2806-2813
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Open Access Status
License
All rights reserved
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Controlled