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Soluble ST2 correlates with some indicators of right ventricular function in hypertensive heart failure
Ojji, Dike Lecour, Sandrine Adeyemi, O. M. Sliwa-Hahnle, Karen
Ojji, Dike
Lecour, Sandrine
Adeyemi, O. M.
Sliwa-Hahnle, Karen
Abstract
Purpose: ST2 receptor, which is a member of the Toll-like/interleukin-1 (IL-1) receptor family, has been found to be increased in the serum of patients 1 day after myocardial infarction. Several other studies have shown that soluble ST2 levels correlate with severity of heart failure (HF), left ventricular ejection fraction, creatinine clearance, B-type natriuretic peptide and C-reactive protein, and are predictors of mortality in HF. Most of these studies were not only limited to ischemic heart disease but also concentrated on left-sided HF. We therefore decided to study the relationship between soluble ST2 and some markers of right ventricular (RV) function in a cohort of hypertensive HF subjects. Patients and methods: This is a prospective cohort study of hypertensive HF patients presenting to the University of Abuja Teaching Hospital, Abuja, over a 12-month period. ST2 was measured in plasma sample by the enzyme-linked immunosorbent assay (ELISA) method. Right ventricular diameters in diastole (RVDD) and right atrial area (RAA) were obtained on echocardiography, while right ventricular systolic pressure (RVSP) was estimated from echocardiography by the addition of the pressure gradient between the right ventricle and right atrium (RA) to the pressure in the RA. Results: There was a significant correlation between RVSP and soluble ST2 (t=0.75, p < 0.0001), RVDD (t=0.28, p=0.004) and RAA (t=0.46, p=0.002). Conclusion: In a cohort of hypertensive HF subjects, soluble ST2 correlates significantly with RVSP, RVDD and RAA.
Keywords
Date
2017
Type
Journal article
Journal
Vascular Health and Risk Management
Book
Volume
13
Issue
Page Range
311-316
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
CC BY-NC 3.0
File Access
Open