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Serum chloride and sodium interplay in patients with acute myocardial infarction and heart failure with reduced ejection fraction: an analysis from the high-risk myocardial infarction database initiative
Ferreira, João P. Girerd, Nicolas Duarte, Kevin Coiro, Stefano McMurray, John Dargie, H. J. Pitt, Bertram Dickstein, Kenneth Testani, Jeffrey M. Zannad, Faiez
Ferreira, João P.
Girerd, Nicolas
Duarte, Kevin
Coiro, Stefano
McMurray, John
Dargie, H. J.
Pitt, Bertram
Dickstein, Kenneth
Testani, Jeffrey M.
Zannad, Faiez
Abstract
Background—Serum chloride levels were recently found to be independently associated with mortality in heart failure (HF). Methods and Results—We investigated the relationship between serum chloride and clinical outcomes in 7195 subjects with acute myocardial infarction complicated by reduced left ventricular function and HF. The studied outcomes were all-cause mortality, cardiovascular mortality, and hospitalization for HF. Both chloride and sodium had a nonlinear association with the studied outcomes (P<0.05 for linearity). Patients in the lowest chloride tertile (chloride ≤100) were older, had more comorbidities, and had lower sodium levels (P<0.05 for all). Serum chloride showed a significant interaction with sodium with regard to all studied outcomes (P for interaction < 0.05 for all). The lowest chloride tertile (≤100 mmol/L) was associated with increased mortality rates in the context of lower sodium (≤138 mmol/L; adjusted hazard ratio [95% confidence interval] for all-cause mortality=1.42 (1.14–1.77); P=0.002), whereas in the context of higher sodium levels ( > 141 mmol/L), the association with mortality was lost. Spline-transformed chloride and its interaction with sodium did not add significant prognostic information on top of other well-established prognostic variables (P > 0.05 for all outcomes). Conclusions—In post–myocardial infarction with systolic dysfunction and HF, low serum chloride was associated with mortality (but not hospitalization for HF) in the setting of lower sodium. Overall, chloride and its interaction with sodium did not add clinically relevant prognostic information on top of other well-established prognostic variables. Taken together, these data support an integrated and critical consideration of chloride and sodium interplay.
Keywords
Alkalosis, anion, attention, heart failure, myocardial infarction
Date
2017
Type
Journal article
Journal
Circulation: Heart Failure
Book
Volume
10
Issue
2
Page Range
1-11
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Controlled