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Mechanisms of cardiotoxicity and the development of heart failure
Lee, Christopher S.
Lee, Christopher S.
Author
Abstract
Key points
• The term, cardiotoxicity, generally refers to toxicity of a substance that negatively affects the heart but also has been described using more precise clinical terms in cancer trials.
• Common mechanisms of cardiotoxicity associated with cancer therapies include direct cardiomyocyte injury, thromboembolic events, and hypertension.
• Anti–tumor necrosis factor (TNF)-α agents used in the treatment of rheumatoid arthritis may interfere with ischemic preconditioning or other roles of low levels of inflammation in cell repair.
• Alcohol results in cardiotoxicity via oxidative stress, apoptosis, mitochondrial stress, and protein catabolism.
• Cocaine is cardiotoxic primarily by means of sympathetic nervous system stimulation of heart and smooth muscle cells.
Keywords
cardiotoxicity, heart failure, pathophysiology, cardiomyopathy, toxicity
Date
2015
Type
Journal article
Journal
Critical Care Nursing Clinics of North America
Book
Volume
27
Issue
4
Page Range
469-481
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled
Notes
© 2015 Elsevier Inc. All rights reserved.