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Making Sense of Statistics in Clinical Trial Reports Part 1 of a 4-Part Series on Statistics for Clinical Trials
Pocock, Stuart J. McMurray, John J.V. Collier, Timothy J.
Pocock, Stuart J.
McMurray, John J.V.
Collier, Timothy J.
Abstract
This paper is a practical guide to the essentials of statistical analysis and reporting of randomized clinical trials (RCTs). It is the first in a series of 4 educational papers on statistical issues for RCTs, which will also include statistical controversies in RCT reporting and interpretation, the fundamentals of design for RCTs, and statistical challenges in the design and monitoring of RCTs. Here, we concentrate on displaying results in tables and figures, estimating treatment effects, expressing uncertainty using confidence intervals, and using p values wisely to assess the strength of evidence for a treatment difference. The various methods and their interpretation are illustrated by recent, topical cardiology trial results. (J Am Coll Cardiol 2015;66:2536–49) © 2015 by the American College of Cardiology Foundation
Keywords
clinical trials, interpretation, publication, statistics
Date
2015
Type
Journal article
Journal
Journal of the American College of Cardiology
Book
Volume
66
Issue
22
Page Range
2536-2549
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Controlled