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Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial
Taaffe, Dennis R. Newton, Robert U. Spry, Nigel A. Joseph, David Chambers, Suzanne K. Gardiner, Robert Alexander Wall, Bradley Alan Cormie, Prue Bolam, Kate Galvao, Daniel A.
Taaffe, Dennis R.
Newton, Robert U.
Spry, Nigel A.
Joseph, David
Chambers, Suzanne K.
Gardiner, Robert Alexander
Wall, Bradley Alan
Cormie, Prue
Bolam, Kate
Galvao, Daniel A.
Abstract
Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43–90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo. Results and limitations: Fatigue was reduced (p = 0.005) in ILRT at 6 mo and 12 mo (∼5 points), and inART (p = 0.005) and DEL (p = 0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤ 0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (ptrend < 0.001). A limitation was inclusion of mostly well-functioning individuals. Conclusions: Different exercise modes have comparable effects on reducing fatigue and enhancing vitality during ADT. Patients with the highest levels of fatigue and lowest vitality had the greatest benefits. Patient summary: We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.
Keywords
exercise, fatigue, Androgen deprivation therapy, prostate cancer, exercise prescription, aerobic exercise, resistance exercise
Date
2017
Type
Journal article
Journal
European Urology
Book
Volume
72
Issue
2
Page Range
293-299
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
CC BY-NC-ND 4.0
File Access
Open