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Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1
Chisholm, Anita K. Lami, Francesca Haebich, Kristina M. Ure, Alex Brignell, Amanda Maloof, Tiba Pride, Natalie A. Walsh, Karin S. Maier, Alice Rouel, Melissa
Chisholm, Anita K.
Lami, Francesca
Haebich, Kristina M.
Ure, Alex
Brignell, Amanda
Maloof, Tiba
Pride, Natalie A.
Walsh, Karin S.
Maier, Alice
Rouel, Melissa
Author
Chisholm, Anita K.
Lami, Francesca
Haebich, Kristina M.
Ure, Alex
Brignell, Amanda
Maloof, Tiba
Pride, Natalie A.
Walsh, Karin S.
Maier, Alice
Rouel, Melissa
Granader, Yael
Barton, Belinda
Darke, Hayley
Fuelscher, Ian
Dabscheck, Gabriel
Anderson, Vicki A.
Williams, Katrina
North, Kathryn N.
Payne, Jonathan M.
Lami, Francesca
Haebich, Kristina M.
Ure, Alex
Brignell, Amanda
Maloof, Tiba
Pride, Natalie A.
Walsh, Karin S.
Maier, Alice
Rouel, Melissa
Granader, Yael
Barton, Belinda
Darke, Hayley
Fuelscher, Ian
Dabscheck, Gabriel
Anderson, Vicki A.
Williams, Katrina
North, Kathryn N.
Payne, Jonathan M.
Abstract
This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.
Keywords
neurofibromatosis type 1, autism, autistic, sex differences, age-related differences, children
Date
2022
Type
Journal article
Journal
Journal of Autism and Developmental Disorders
Book
Volume
53
Issue
Page Range
2835-2850
Article Number
ACU Department
School of Allied Health
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled