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The variability of MR axon radii estimates in the human white matter
Veraart, Jelle Raven, Erika P. Edwards, Luke J. Weiskopf, Nikolaus Jones, Derek K.
Veraart, Jelle
Raven, Erika P.
Edwards, Luke J.
Weiskopf, Nikolaus
Jones, Derek K.
Abstract
The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner test–retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient-of-variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test–retest analysis, but it is shown that the performance can be improved fourfold using a customized along-tract analysis.
Keywords
axon diameter, diffusion MRI, reproducibility, variability
Date
2021
Type
Journal article
Journal
Human Brain Mapping
Book
Volume
42
Issue
7
Page Range
2201-2213
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open