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Brain-derived neurotrophic factor association with amygdala response in major depressive disorder
Lorenzetti, Valentina Costafreda, Sergi G. Rimmer, Rachael M. Rasenick, Mark M. Marangell, Lauren B. Fu, Cynthia H. Y.
Lorenzetti, Valentina
Costafreda, Sergi G.
Rimmer, Rachael M.
Rasenick, Mark M.
Marangell, Lauren B.
Fu, Cynthia H. Y.
Abstract
Background
Brain-derived neurotrophic factor (BDNF) has an essential role in synaptic plasticity and neurogenesis. BDNF mediates amygdala-dependent learning for both aversive and appetitive emotional memories. The expression of BDNF in limbic regions is posited to contribute the development of depression, and amygdala responsivity is a potential marker of depressive state.
Methods
The present study examined the relationship between platelet BDNF levels and amygdala volume and function in major depressive disorder (MDD). Participants were 23 MDD (mean age 38.9 years) and 23 healthy controls (mean age 38.8 years). All participants were recruited from the community. MDD participants were in a current depressive episode of moderate severity and medication-free. Amygdala responses were acquired during a functional MRI task of implicit emotional processing with sad facial expressions.
Results
Significant correlation was observed between platelet BDNF levels and left amygdala responses, but no significant correlations were found with right amygdala responses or with amygdala volumes.
Limitations
Interactions with neuroprotective as well as neurotoxic metabolites in the kyneurenine pathway were not examined.
Conclusions
Relationship between BDNF levels and amygdala responsivity to emotionally salient stimuli in MDD could reflect the importance of BDNF in amygdala-dependent learning with clinical implications for potential pathways for treatment.
Keywords
BDNF, depression, amygdala, plasticity
Date
2020
Type
Journal article
Journal
Journal of Affective Disorders
Book
Volume
267
Issue
Page Range
103-106
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as green open access
License
File Access
Open
Controlled
Controlled