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Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults
Scott, D. Trbojevic, T. Skinner, E. Clark, R. A. Levinger, P. Haines, T. P. Sanders, K. M. Ebeling, P. R.
Scott, D.
Trbojevic, T.
Skinner, E.
Clark, R. A.
Levinger, P.
Haines, T. P.
Sanders, K. M.
Ebeling, P. R.
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Abstract
Objectives: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. Methods: 48 community-dwelling older adults aged ≥65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2 ) and muscle density (mg/cm3 ; higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). Results: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95%CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P<0.03), while higher muscle density was associated with smaller step width (P<0.01) only. Conclusions: Older adults with higher calf IMAT have poorer balance, mobility and inflammatory status. Interventions aimed at improving physical function in older adults should incorporate strategies to reduce IMAT.
Keywords
intermuscular adipose tissue, sarcopenia, balance, mobility, ageing
Date
2015
Type
Journal article
Journal
The Journal of Musculoskeletal and Neuronal Interactions
Book
Volume
15
Issue
4
Page Range
350-357
Article Number
ACU Department
Non-faculty
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DOI
Event URL
Open Access Status
License
File Access
Controlled