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Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study
Lim, Yen Ying Ellis, Kathryn A. Harrington, Karra J. Ames, David Martins, Ralph N. Masters, Colin L. Rowe, Christopher C. Savage, Greg Szoeke, Cassandra Darby, David
Lim, Yen Ying
Ellis, Kathryn A.
Harrington, Karra J.
Ames, David
Martins, Ralph N.
Masters, Colin L.
Rowe, Christopher C.
Savage, Greg
Szoeke, Cassandra
Darby, David
Abstract
The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ϵ4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.
Keywords
Alzheimer's disease, CogState, Australian Imaging, biomarkers and Lifestyle study, apolipoprotein E ϵ4, cognitive testing
Date
2012
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Journal article
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Journal of Clinical and Experimental Neuropsychology
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