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Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people
del Pozo-Cruz, Jesús Rodríguez-Bies, Elizabeth Navas-Enamorado, Ignacio del Pozo-Cruz, Borja Navas, Plácido López-Lluch, Guillermo
del Pozo-Cruz, Jesús
Rodríguez-Bies, Elizabeth
Navas-Enamorado, Ignacio
del Pozo-Cruz, Borja
Navas, Plácido
López-Lluch, Guillermo
Abstract
The impact of aging and physical capacity on coenzyme Q10 (Q10) levels in human blood is unknown. Plasma Q10 is an important factor in cardiovascular diseases. To understand how physical activity in the elderly affects endogenous Q10 levels in blood plasma, we studied a cohort of healthy community-dwelling people. Volunteers were subjected to different tests of the Functional Fitness Test Battery including handgrip strength, six-minute walk, 30 s chair to stand, and time up and go tests. Anthropometric characteristics, plasma Q10 and lipid peroxidation (MDA) levels were determined. Population was divided according to gender and fitness. We found that people showing higher levels of functional capacity presented lower levels of cholesterol and lipid peroxidation accompanied by higher levels of Q10 in plasma. The ratio Q10/cholesterol and Q10/LDL increased in these people. No relationship was found when correlated to muscle strength or agility. On the other hand, obesity was related to lower Q10 and higher MDA levels in plasma affecting women more significantly. Our data demonstrate for the first time that physical activity at advanced age can increase the levels of Q10 and lower the levels of lipid peroxidation in plasma, probably reducing the progression of cardiovascular diseases.
Keywords
aging, coenzyme Q10, cardiovascular disease, fitness, obesity, physical activity
Date
2014
Type
Journal article
Journal
Experimental Gerontology
Book
Volume
52
Issue
Page Range
46-54
Article Number
ACU Department
Institute for Positive Psychology and Education
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled